Results 81 to 90 of about 2,942,401 (279)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

The Journalist-as-Guest Format in Daily Deep Dive Podcasts: Building Authority Claims Through Metajournalistic Conversation

open access: yesJournalism and Media
This paper examines how conversational daily deep dive news podcasts build journalistic authority and legitimacy through what we call the “journalist-as-guest” (JAG) format. Applying a deep analytical listening methodology that honors the aurality of the
Gabriela Perdomo, Mia Lindgren
doaj   +1 more source

Keine News und dann?

open access: yesMedien & Zeit, 2023
Wie zahlreiche Studien zur journalistischen Nachrichtennutzung von jungen Menschen zeigen, hat sich die Art und Weise des Zugangs zu solchen Inhalten im Umfeld von digitalen Plattformen stark verändert.
Ulla Authenrieth   +2 more
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Üniversite Öğrencilerinin Eleştirel Sosyal Medya Okuryazarlığı ve Haberden Kaçınma Davranışı: Pasif İlgisizlikten Seçici Katılıma

open access: yesErciyes İletişim Dergisi
Çalışma, üniversite öğrencilerinin eleştirel sosyal medya okuryazarlığı (ESMO) düzeylerini, söz konusu düzeylerin demografik ve eğitsel değişkenler doğrultusunda nasıl farklılaştığını ve haberden kaçınma davranışlarıyla olan çok boyutlu ilişkisini ...
Özge Ercebe, Erdem Öngün
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Simulation discussed : tax avoidance in the common law [PDF]

open access: yes, 2012
Includes bibliographical references.The simulation doctrine has, in the law of taxation, always played the role of being SARS' remedy in the common law, vis-a-vis its legislated cohorts, viz.
Marais, Albertus Johannes
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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