Results 141 to 150 of about 3,444,607 (339)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Decoding the News Media Diet of Disinformation Spreaders

Entropy
In the digital era, information consumption is predominantly channeled through online news media and disseminated on social media platforms. Understanding the complex dynamics of the news media environment and users’ habits within the digital ecosystem ...
Anna Bertani, Valeria Mazzeo, Riccardo Gallotti   +2 more
doaj   +1 more source

Media Use and Political Engagement: Cross-Cultural Approaches| Between Individual and Collective Social Effort: Vocabularies of Informed Citizenship in Different Information Environments

International Journal of Communication, 2023
Information disorder and digital media affordances challenge informed citizenship as an ideal and in practice. While scholars have attempted to adapt the normative ideal to contemporary changes and challenges by introducing new metaphors and normative ...
Emilija Gagrčin, Pablo Porten-Cheé
doaj  

News Shocks and Learning-by-doing [PDF]

The idea that expectations about future economic fundamentals can drive business cycles dates back to the early twentieth century. However, the standard real business cycle (RBC) model fails to generate positive comovement in output, consumption, labor ...
Hammad Qureshi
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Everyday the Same Picture: Popularity and Content Diversity [PDF]

, 2015
Facebook is flooded by diverse and heterogeneous content, from kittens up to music and news, passing through satirical and funny stories. Each piece of that corpus reflects the heterogeneity of the underlying social background. In the Italian Facebook we
Bessi, Alessandro, Del Vicario, Michela, Gonçalves, Bruno, Petroni, Fabio, Quattrociocchi, Walter, Scala, Antonio, Zollo, Fabiana   +6 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Habits, Sentiment and Predictable Income in the Dynamics of Aggregate Consumption [PDF]

This paper explores whether habit formation in the representative agent’s preferences can explain two failures of the standard permanent income model: the sensitivity to lagged consumer sentiment, and to predictable changes in income.
Martin Sommer
core  

Hate, amplified? Social media news consumption and support for anti-Muslim policies. [PDF]

J Public Policy, 2022
Lajevardi N, Oskooii KAR, Walker H.
europepmc   +1 more source