Results 51 to 60 of about 35,861 (262)

China's Energy Consumption in the New Normal [PDF]

Earth's Future, 2018
AbstractEnergy consumption is one of main reasons for global warming and highly correlated with economic development. As the largest energy consumer worldwide, China has entered a new economic development model—the “new normal.” This study aims to explore the pattern shift in China's energy consumption growth in this new development phase.
Zhifu Mi, Jiali Zheng, Jing Meng, Yuli Shan, Heran Zheng, Jiamin Ou, Dabo Guan, Yi‐Ming Wei   +7 more
openaire   +5 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The Knowledge Gap Hypothesis Across Modality: Differential Acquisition of Knowledge From Television News, Newspapers, and News Websites

International Journal of Communication, 2019
This study investigates how Tichenor’s hypothesized “knowledge gap” is affected differently by different modalities of news media. Measuring the acquisition of new surveillance facts in subsequent survey waves, we modeled how strongly people’s level of ...
Mark Boukes, Rens Vliegenthart
doaj  

Understanding Public Concerns About Fake News: Linking Social Media News Use, Cognitive Elaboration, and Perceived Fake News Exposure

International Journal of Communication
Over the past decade, the exponential growth of information consumption through social media has reshaped the media landscape in most liberal democracies. This shift has introduced significant challenges, particularly the spread of fake news and growing
Manuel Goyanes, Taeyoung Lee
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

News Won’t Find Me? Exploring Inequalities in Social Media News Use With Tracking Data

International Journal of Communication, 2022
The rise of news content on social media has been accompanied by a hope that people with lower socioeconomic status and less interest in political affairs would be “accidentally” exposed to news.
Lisa Merten, Nadia Metoui, Mykola Makhortykh, Damian Trilling, Judith Moeller   +4 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Nonlinear news production and consumption

Computers in Entertainment, 2009
People depend on news to make sense of happenings in the world, but current digital news products do not live up to their potential in this regard. Interactivity in relation to news is often seen as a way to give the consumer control over when to consume something and on which platform. Less attention has been placed on what should be consumed and how.
Lindstedt, Inger, Löwgren, Jonas, Reimer, Bo, Topgaard, Richard   +3 more
openaire   +3 more sources