Results 41 to 50 of about 54,455 (325)

Looking for Local News: Information Sources and Perceptions About (Dis)information Where There Is (No) Media

open access: yesRevista Comunicando
In recent years, the concept of news deserts has aroused the curiosity of many scholars and regulators around the world, being defined as communities without a local newspaper or communities where residents face significantly reduced access to the news ...
Luísa Torre
doaj   +1 more source

Democracia, informação e mídia local para superar os desertos de notícias: entrevista com Penny Abernathy

open access: yesComunicação & Educação, 2023
Specialist and master in Journalism with an intense editorial and media management background, Penny Abernathy has become a reference among Brazilian researchers of the area after developing the concept of “news deserts.” The reports led by Abernathy ...
Sonia Virgínia Moreira   +1 more
doaj  

Deserts of Development: How God Shapes Leaders in the Wilderness [PDF]

open access: yes, 2010
A wilderness experience in the life of a believer is often a tool used by God to shape him for some leadership position or specific calling. While the desert one is thrust into may be physical in nature or purely psychological, wilderness experiences ...
Dickson, Jeffrey R
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Our Mission to Planet Earth: A Guide to Teaching Earth System Science [PDF]

open access: yes, 1994
This teaching guide provides hands-on activities and information related to studying the Earth system. Its primary goal is for children to become familiar with the concept of cycles and to learn that some human activities can cause changes in their ...

core  

Policy initiatives to address low-income households’ nutritional needs in the UK [PDF]

open access: yes, 2007
Members of low-income households in the UK are more likely to have patterns of food and nutrient intakes that are less inclined to lead to good health outcomes in the short and long term.
Acheson   +40 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Evolutionary-new centromeres preferentially emerge within gene deserts [PDF]

open access: yesGenome Biology, 2008
Abstract Background Evolutionary-new centromeres (ENCs) result from the seeding of a centromere at an ectopic location along the chromosome during evolution. The novel centromere rapidly acquires the complex structure typical of eukaryote centromeres.
Lomiento M   +4 more
openaire   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

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