Results 51 to 60 of about 54,455 (325)

No. 03: Urban Food Deserts and Climate Change in African Cities [PDF]

, 2016
The underlying assumption in much of the Euro-American food deserts literature is that urban food deserts are dynamic spaces, expanding and contracting with the advent and withdrawal of supermarkets. This discussion paper argues that to tie such dynamism
Caesar, Mary, Crush, Jonathan
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Access to shops: The views of low-income shoppers [PDF]

, 2000
Concern is mounting as the retail stranglehold upon access to food grows. Research on the implications of restructuring retailing and health inequality has failed to involve low-income consumers in this debate. This paper reports on an exercise conducted
Acheson D., Bach M., Caraher M., Caraher M., Cranbrook C., Cws., Department of Environment, Department of Health., Department of Health., Department of Social Security., Dobson B., Donkin Ajm, Dowler E., Dowler E., Dowler E., Forbes A., Germov J., Harrison M., House of Commons Select Committee on the Environment., Kaufman PR, Lang T., Leather S., Lisc., Marsden T., Martin Caraher, Matheson J, Nicola Robinson, O'Connor JJ, Peston, The Lord, Peters T., Piachaud D., Pickering JF, Porter S., Reisig V., Seth A., Social Exclusion Unit., Tim Lang, Whitehead M.   +37 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Hyperlocals and Legacy Media: Media Ecologies in Transition

Nordicom Review, 2018
Declining legacy media seriously affects local journalism in Sweden. Since 2004, nearly every second local office for local newspapers has been closed, and local coverage is diminishing.
Nygren Gunnar, Leckner Sara, Tenor Carina   +2 more
doaj   +1 more source

Soil Health Indicators and Sustainable Practices on Indy Urban Farms: An Investigation of Ecosystem Functionality [PDF]

, 2019
Urban agriculture is capable of restoring ecosystem services like food production, recreation, and clean soil and water to cities. Urban farms in particular can help relieve pressure for areas with limited food access, also known as food desserts.
Lewis, Rebecca
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Academic news partnerships in local journalism: A literature review

Facts & Frictions
This literature review investigates the potential of college and university newsrooms to mount a response to the decline of local journalism in Canada.
Teresa Goff, Izza Adil, Sunmeet Kour, Gage Patte   +3 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

City of Strangers: Gulf Migration and the Indian Community in Bahrain [PDF]

, 2010
{Excerpt} Unpacking and applying the concept of structural violence is one of the principal tasks of this book. To be clear from the outset, however, in lodging the experiences of the men and women I encountered in the larger rubric of structural ...
Gardner, Andrew M.
core   +2 more sources