Results 51 to 60 of about 376,842 (294)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Resounding News: The Acoustic Conventions of Israeli Newscasts

International Journal of Communication, 2017
 This article takes sound as its analytical point of departure in asking the following question: What does sound do in television news? Exploring the conventions of sound used by producers of Israeli television news, from the signature tune to the ...
Hadar Levy, Amit Pinchevski
doaj   +2 more sources

Framing the cuts: an analysis of the BBC’s discursive framing of the ConDem cuts agenda [PDF]

, 2013
This study analyses the discursive framing of the British government’s economic policies by BBC News Online. Specifically, it focuses on the coverage of the government’s Comprehensive Spending Review in 2010, in which the details of the Chancellor of
Kay, Jilly Boyce, Salter, Lee
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

News Framing and the Applicability of Authoritarian Values: Citizens’ Reasoning on News About Societal Disorder

International Journal of Communication
Tensions between liberal and authoritarian values have gained increasing significance within Western democracies. This focus-group study contributes to the research on the dynamics of authoritarianism, providing in-depth analyses of the interactions ...
Mats Ekström, Maria Jervelycke Belfrage
doaj   +2 more sources

Framing marijuana: How U.S. newspapers frame marijuana legalization stories (1995–2014)

Preventive Medicine Reports, 2018
Marijuana legalization has been one of the most controversial issues in the public health field. Since news frames can influence the public's perceptions about public health policy including marijuana legalization, it is important to understand how the ...
Hwalbin Kim, Sei-Hill Kim
doaj   +1 more source

Wacana Pencalonan Rhoma Irama sebagai Calon Presiden dalam Pemilihan Presiden 2014 dalam Bingkai Surat Kabar Harian KOMPAS [PDF]

, 2014
Wacana pencalonan Rhoma Irama menjadi presiden Republik Indonesia mengundangbanyak pro dan kontra pada kalangan politisi. KOMPAS sebagai salah satu media massanasional yang popular juga mempunyai peran dalam menyebarkan berita melalui tulisannya.Oleh ...
Nugroho, A. (Adi), Prayoga, I. (Indra), Rakhmad, W. N. (Wiwid), Yulianto, M. (Much)   +3 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Counter-Framing Effects of User Comments

International Journal of Communication, 2019
Past research shows that news frames shape audience reactions to news messages. As individuals receive more of their news online, where many news messages are accompanied by opportunities for audience members to comment, it has become important to ...
Jiawei Liu, Douglas M. McLeod
doaj   +2 more sources