Results 171 to 180 of about 2,191,018 (312)
Identification of inhibitors of the Salmonella FraB deglycase, a drug target
FEBS Open Bio, EarlyView.A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang +7 more
wiley +1 more source
Mapping Hsp104 interactions using cross‐linking mass spectrometry
FEBS Open Bio, EarlyView.This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal +3 more
wiley +1 more source
Headlines win elections: Mere exposure to fictitious news media alters voting behavior. [PDF]
PLoS One, 2023 Pfister R +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya +3 more
wiley +1 more source
Examining the quality of news media reporting of complex mental illness in relation to violent crime in Australia. [PDF]
Int J Soc Psychiatry, 2023 Graham M, Morgan A, Paton E, Ross A.
europepmc +1 more source
Embedding Elites: Examining the Use of Tweets Embedded in Online News Articles across Reliable and Fringe Outlets [PDF]
arXivThis study examines the use of embedded tweets in online news media. In particular, we add to the previous literature by exploring embedded tweets across reliable and unreliable news outlets. We use a mixed-method analysis to examine how the function and frequency of embedded tweets change across outlet reliability and news topic.
arxiv
FEBS Open Bio, EarlyView.The C. elegans tetraspanin‐7 (tsp‐7) is a homologue of human CD63, which is a negative regulator of autophagy. The C. elegans strain, tm5761, has a dysfunctional (knockout) tsp‐7 gene. When compared to the wild‐type strain, the tm5761 strain shows increased: life‐ and health‐span; thermotolerance, and stress‐induced locomotion.
Brogan Jones +2 more
wiley +1 more source
True, justified, belief? Partisanship weakens the positive effect of news media literacy on fake news detection. [PDF]
Front Psychol, 2023 Sude DJ, Sharon G, Dvir-Gvirsman S.
europepmc +1 more source