Results 41 to 50 of about 19,825,415 (296)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Digital Inclusion Through Algorithmic Knowledge: Curated Flows of Civic and Political Information on Instagram

Media and Communication
Social media platforms are a critical source of civic and political information. We examine the use of Instagram to acquire news as well as civic and political information using nationally representative survey data gathered in 2019 in the US, the UK ...
Shelley Boulianne, Christian P. Hoffmann
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Design of news sentiment classification and recommendation system based on multi-model fusion and text similarity

International Journal of Cognitive Computing in Engineering
To improve the performance of the news recommendation system, the study employs a multi-model fusion strategy in conjunction with three classification methods to improve the accuracy of sentiment classification.
Qinchen Xi, Peiyun Jiang
doaj   +1 more source

Nudge Effect of Fact-Check Alerts: Source Influence and Media Skepticism on Sharing of News Misinformation in Social Media

Social Media + Society, 2020
This study extends the nudge principle with media effects and credibility evaluation perspectives to examine whether the effectiveness of fact-check alerts to deter news sharing on social media is moderated by news source and whether this moderation is ...
Elmie Nekmat
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Wartawan Media Now dalam Mengemas Berita: Perspektif Situational Theory [PDF]

, 2015
The study aims to map and describe relationships between concepts of activity of journalists in the media now cloning technology based activities and relationship between news reporters. This study discusses the focus of news coverage in media activities
Anisti Anisti, Anisti, Anisti, Hidayat, Dasrun, Dasrun Hidayat   +3 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Hashtag activism and feminisms: a study on the Sabarimala temple entry in India

Cogent Arts & Humanities
Feminism in India has been evolving in recent decades, with acknowledgment of intersectionality, the dynamic interrelationship between caste, class, religious and regional identities in media representations of women.
Swapna Gopinath, Neha Jindal
doaj   +1 more source