Results 91 to 100 of about 28,802,758 (291)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The interplay of news media, social media, and public search behavior during the 2022–2023 South Korea drought

Humanities & Social Sciences Communications
Drought is a creeping phenomenon that aggravates adverse impacts over time, eventually altering emotion and social behavior. Web search engine, news media, and social media trace changes of public search behavior and online communication during the ...
Seunghui Choi, Anqi Liu, Sangeun Lee, Hyeoncheol Yoon, Jonghun Kam   +4 more
doaj   +1 more source

Which Exerts Greater Influence? Domestic vs. International News Media on Belt and Road Initiative (BRI) Projects in Myanmar

Journalism and Media
Previous studies have investigated media influence on public opinion regarding BRI projects in Myanmar but have not clarified whether domestic or international news media exert more influence.
Zeyar Oo, Yonghong Dai, Xiang Zhou, Lok Bahadur B. K., Poudel Ashok, Bandana Singh   +5 more
doaj   +1 more source

Patient healthcare experiences in the Northwest Territories, Canada: an analysis of news media articles. [PDF]

Int J Circumpolar Health, 2021
Cooper R, Pollock NJ, Affleck Z, Bain L, Hansen NL, Robertson K, Chatwood S.   +6 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

American Indians in the News: A Media Portrayal in Crime Articles

American Indian Culture and Research Journal, 2007
As one of the most recognized social problems, crime represents a constant focus of many media accounts in television, movies, and newspapers. Crime stories are a staple of day-to-day newspaper reporting;1 thus the media may profoundly shape the public’s stereotypes and beliefs toward crime and perpetrators of criminal activity.2 Individuals’ notions ...
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Detection of Political Hoax News Using Fine-Tuning IndoBERT

Journal of Applied Informatics and Computing
Indonesia has experienced a surge in the spread of political hoax news, posing a potential threat to democratic and social stability. This study aims to develop a model for detecting political hoax news in the Indonesian language using IndoBERT, a ...
Charlotte Jocelynne, IGN Lanang Wijayakusuma, Luh Putu Ida Harini   +2 more
doaj   +1 more source

Chinese newspaper coverage of genetically modified organisms

BMC Public Health, 2012
Background Debates persist around the world over the development and use of genetically modified organisms (GMO). News media has been shown to both reflect and influence public perceptions of health and science related debates, as well as policy ...
Du Li, Rachul Christen
doaj   +1 more source