Results 141 to 150 of about 73,385 (311)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Sharing the news : Dissemination of links to Australian news sites on Twitter
, 2013 Social media adoption in Australia, which provides the geographic focus for this chapter, has been rapid and substantial (ABC News, 2010) – possibly because of the considerable dispersal of the Australian population across the continent, as well as the ...
Highfield, Tim +4 more
core
International Journal of Communication, 2019 This study aims to identify the determinants and consequences of news authorship verification in the context of news aggregation sites. Checking news authorship becomes important where countless news articles produced by numerous authors are distributed
Sujin Choi, Jihoon Lim
doaj
A qualitative study of the coverage of influenza vaccination on Dutch news sites and social media websites. [PDF]
BMC Public Health, 2013 Lehmann BA, Ruiter RA, Kok G.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Evaluating WAP News Sites: The WEBQUAL/M Approach
, 2001 This paper reports on the evaluation of wireless Internet news sites using the WebQual/m instrument. From initial application in the domain of traditional Internet Web sites, the instrument has been adapted for sites delivered using the wireless ...
Liu, Kenny +2 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
High Fidelity Web Archiving of News Sites and New Media with Browsertrix
This paper discusses how Webrecorder’s free and open source browser-based web archiving tools such as Browsertrix can and have been used by libraries and archives to create and provide access to high fidelity web archives of online news sites, social ...
Walsh, Tessa +2 more
core +1 more source