Results 121 to 130 of about 11,303,291 (302)

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

open access: yesAdvanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li   +8 more
wiley   +1 more source

A Newton Collocation Method for Solving Dynamic Bargaining Games [PDF]

open access: yes
We develop and implement a collocation method to solve for an equilibrium in the dynamic legislative bargaining game of Duggan and Kalandrakis (2008). We formulate the collocation equations in a quasi-discrete version of the model, and we show that the ...
John Duggan, Tasos Kalandrakis
core  

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren   +11 more
wiley   +1 more source

Two-step inexact Newton-like method for solving generalized inverse eigenvalue problems

open access: yesResults in Applied Mathematics
In this paper, based on two-step Newton iterative procedure, we propose a two-step inexact Newton-like method for generalized inverse eigenvalue problems. Under some mild assumptions, our results show that the two-step inexact Newton-like method is super
Liuqing Hua, Wei Ma
doaj   +1 more source

A Riemannian Proximal Newton Method

open access: yesSIAM Journal on Optimization
Updates compared to the previous version: *) the updates for the published version. Additionally updates: *) local quadratic convergence rate *) update the proofs of Lemma 3.3.
Wutao Si   +4 more
openaire   +4 more sources

Data for: Newton et al. 2020 The number and spatial distribution of forest-proximate people globally. One Earth

open access: yes
We include files relevant to the paper Newton et al. 2020 The number and spatial distribution of forest-proximate people globally, published in the journal One Earth. The files included are: 1) Table S1.
Newton, Peter
core   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

open access: yesAdvanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao   +12 more
wiley   +1 more source

Cluster Gauss-Newton method analyses of PBPK model parameter combinations of coproporphyrin-I based on OATP1B-mediated rifampicin interaction studies. [PDF]

open access: yesCPT Pharmacometrics Syst Pharmacol, 2022
Yoshikado T   +6 more
europepmc   +1 more source

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