Results 161 to 170 of about 1,444,385 (351)

Current Status of Next-Generation Sequencing Approaches for Candidate Gene Discovery in Familial Parkinson´s Disease [PDF]

, 2022
Nikita Simone Pillay, Owen A. Ross, Alan Christoffels, Soraya Bardien   +3 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women

Frontiers in Immunology
IntroductionDuring gestation the immune system undergoes dramatic remodelling to protect the maternal-fetal dyad from infections whilst also preventing fetal rejection.
Madhuri S. Salker, Nor Haslinda Abd Aziz, Natalia Carman Prodan, Zhiqi Yang, Aditya Kumar Lankapalli, Katrin Lazar, Mohamad Nasir Shafiee, Ersoy Kocak, Ersoy Kocak, Harivignesh Ganesan, Surya Sekhar Pal, Omer Khalid, Norhana Mohd Kasim, Aida Kalok, Norashikin Abdul Fuad, Alfred Lennart Bissinger, Tina Ganzenmueller, Thomas Iftner, Karl Oliver Kagan, Stephan Ossowski, Stephan Ossowski, Nicolas Casadei, Nicolas Casadei, Sara Y. Brucker, Olaf Riess, Olaf Riess, Yogesh Singh, Yogesh Singh, Yogesh Singh, Deutsche COVID-19 OMICS Initiative (DeCOI)   +29 more
doaj   +1 more source

Case Report: Diagnosis of Human Alveolar Echinococcosis via Next-Generation Sequencing Analysis [PDF]

, 2021
Ke Li, Yubao Ma, Rui Ban, Qiang Shi
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A metagenomic investigation of the faecal RNA virome structure of asymptomatic chickens obtained from a commercial farm in Durban, KwaZulu-Natal province, South Africa

BMC Genomics
Background Virome studies on birds, including chickens are relatively scarce, particularly from the African continent. Despite the continuous evolution of RNA viruses and severe losses recorded in poultry from seasonal viral outbreaks, the information on
Vivian C. Nwokorogu, Santhosh Pillai, James E. San, Charlene Pillay, Martin M. Nyaga, Saheed Sabiu   +5 more
doaj   +1 more source

Validation and Implementation of a Custom Next-Generation Sequencing Clinical Assay for Hematologic Malignancies

, 2016
Michael Kluk, R. Coleman Lindsley, Jon C. Aster, Neal I. Lindeman, David Szeto, Dimity Hall, Frank C. Kuo   +6 more
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Diversity of Picorna-Like Viruses in the Teltow Canal, Berlin, Germany

Viruses
The viromes of freshwater bodies are underexplored. The Picornavirales order, with 371 acknowledged species, is one of the most expansive and diverse groups of eukaryotic RNA viruses.
Roland Zell, Marco Groth, Lukas Selinka, Hans-Christoph Selinka   +3 more
doaj   +1 more source

Next generation sequencing and comparative analyses of Xenopusmitogenomes [PDF]

, 2012
Foster, P., Guille, Matt, Littlewood, D., Lloyd, Rhiannon   +3 more
core   +1 more source