Results 181 to 190 of about 973,339 (276)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Identification of autosomal and sex chromosome aneuploidies using next generation sequencing. [PDF]

Bioinformatics
Barco-Armengol N, Yubero D, Xiol C, Catasús N, Martí-Sánchez L, Armstrong J, Palau F, Fernandez G.   +7 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Trends and Disparities in the Use of Next-Generation Sequencing in Patients With Cancer in the United States.

JAMA Netw Open
Hage Chehade C, Ozay ZI, Jo Y, Gebrael G, Sayegh N, Ostrowski M, Srivastava A, Garg D, Hardy T, Murdock EG, Narang A, Mathew Thomas V, Li H, Maughan BL, Roy S, Agarwal N, Swami U.   +16 more
europepmc   +1 more source

Broad-spectrum targeted next-generation sequencing: is it ready for routine deployment in intensive care units for severe pneumonia? [PDF]

Crit Care
Tseng HY, Fu YC, Su YH, Kuo YC, Liang SJ, Shen YC, Chen WC, Chen CL, Lin YC, Cheng MY, Chen CH, Tu CY, Lai ZL, Hsueh PR.   +13 more
europepmc   +1 more source

Rapid development of microsatellite markers for Culicoides obsoletus using next generation sequencing [PDF]

, 2015
Argout, Xavier, Balenghien, Thomas, Gardes, Laëtitia, Garros, Claire, Huber, Karine, Rivallan, Ronan, Vignes, Hélène   +6 more
core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Real-World Implementation of Next-Generation Sequencing in Sarcoma: Molecular Insights and Therapeutic Outcomes. [PDF]

Med Sci (Basel)
Diab T, Tarhini A, Jaber G, Raffoul C, Zeineddine N, Kreidieh L, Hemade A, Barake M, Saghieh S, Mahfouz R, Assi HI.   +10 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source