Results 241 to 250 of about 1,444,385 (351)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Clinical application of metagenomic next-generation sequencing in the diagnosis of severe pneumonia pathogens. [PDF]

Front Cell Infect Microbiol
Huang R, Zhang Y, Dong C, Chen J, Zou H, Liu Y, Guo M, Gao H, Ke Q, Wu W.   +9 more
europepmc   +1 more source

PGS analysis of over 100,000 blastocysts using high resolution next generation sequencing [PDF]

, 2017
Sarthak Sawarkar, Matthew J. Large, E. Fragouli, Dan E. Wells, T. Escudero, L. Ribustello, J Blazek, Santiago Munné   +7 more
openalex   +1 more source

Contribution of next generation sequencing to the diagnosis of inborn errors of immunity in a pediatric cohort. [PDF]

Front Immunol
Godinez-Zamora GF, Baeza-Capetillo P, Saucedo-Ramírez OJ, Del-Río-Navarro BE, Espinosa-Padilla SE, Morán-Barroso VF, Aguirre-Hernandez J.   +6 more
europepmc   +1 more source

Overview of Next‐Generation Sequencing Technologies

Current Protocols in Molecular Biology, 2018
B. Slatko, A. F. Gardner, F. Ausubel
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Next Generation Sequencing in Defining the Composition of Bacterial Microbiota of Donated Human Milk. [PDF]

Pediatr Gastroenterol Hepatol Nutr
Novoselac J, Pavunc AL, Čuljak N, Ježek D, Bošnjak Z, Ćepulić BG.   +5 more
europepmc   +1 more source

Impact of Next-Generation Sequencing on Outcomes in Hepatocellular Carcinoma: How Precise Are We Really?

, 2020
Dominguez DA, Xiaowo Wang
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source