Results 281 to 290 of about 1,460,723 (393)

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Overview of Next‐Generation Sequencing Technologies

Current Protocols in Molecular Biology, 2018
B. Slatko, A. F. Gardner, F. Ausubel
semanticscholar   +1 more source

Comparative of metagenomic and targeted next-generation sequencing in lower respiratory tract fungal infections. [PDF]

Front Cell Infect Microbiol
Chen Z, Liu X, Tan L, Lyu X, Long Q, Wu W, Guo Z, Liu Z, Li Z, Hu M.   +9 more
europepmc   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions [PDF]

, 2011
Weixin Wang, Zhi Wei, Tak‐Wah Lam, Junwen Wang   +3 more
openalex   +1 more source

Next-generation sequencing in cancer diagnosis and treatment: clinical applications and future directions. [PDF]

Discov Oncol
Ghoreyshi N, Heidari R, Farhadi A, Chamanara M, Farahani N, Vahidi M, Behroozi J.   +6 more
europepmc   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Next generation sequencing in a family with autosomal recessive Kahrizi syndrome (OMIM 612713) reveals a homozygous frameshift mutation in SRD5A3

, 2010
Kimia Kahrizi, Cougar Hao Hu, Masoud Garshasbi, Seyedeh Sedigheh Abedini, Shirin Ghadami, Roxana Kariminejad, Reinhard Ullmann, Wei Chen, H-Hilger Ropers, Andreas W. Kuß, Hossein Najmabadi, Andreas Tzschach   +11 more
openalex   +2 more sources

Estimation of bacterial diversity using next generation sequencing of 16S rDNA: a comparison of different workflows [PDF]

, 2011
Jorge Barriuso, Jósé R. Valverde, Rafael P. Mellado   +2 more
openalex   +1 more source

A Retrospective Analysis of Ambiguous Spitz Tumors Using Next-Generation Sequencing. [PDF]

Cancers (Basel)
Teufer M, Theiler M, Lanz J, Weibel L, Wagner U, Levesque MP, Kamarachev J, Dummer R, Ramelyte E.   +8 more
europepmc   +1 more source