Results 271 to 280 of about 1,096,418 (305)

[Next Generation Sequencing and ADPKD].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2015
Autosomal Dominant Polycistic Kidney Disease (ADPKD) is the most common inherited genetic disorder in the word, caused by mutations in PKD1 gene in 85% of cases and PKD 2 gene in the remaining 15%. Although diagnosis is usually based on ultrasound, MRI and CT scans, in some cases genetic testing is necessary, for example, in patients with atypical ...
Restivo, Arianna, Di Fruscio, Giuseppina, Masella, Cristina, Rinaldi, Luca, Capolongo, Giovanna, Raiola, Ilaria, Capasso, Giovambattista   +6 more
openaire   +4 more sources

Next-generation sequencing in the clinic

Nature Biotechnology, 2013
Pools of cell lines carrying a variety of known mutations are used to validate the performance of a cancer diagnostic test based on next-generation sequencing.
Jason Y. Park, Larry J. Kricka, FORTINA, PAOLO   +2 more
openaire   +3 more sources

Sequencing the next generation of glioblastomas

Critical Reviews in Clinical Laboratory Sciences, 2018
The most aggressive brain malignancy, glioblastoma, accounts for 60-70% of all gliomas and is uniformly fatal. According to the molecular signature, glioblastoma is divided into four subtypes (proneural, neural, classical, and mesenchymal), each with its own genetic background.
openaire   +2 more sources

Next-Generation Sequencing Platforms

Annual Review of Analytical Chemistry, 2013
Automated DNA sequencing instruments embody an elegant interplay among chemistry, engineering, software, and molecular biology and have built upon Sanger's founding discovery of dideoxynucleotide sequencing to perform once-unfathomable tasks. Combined with innovative physical mapping approaches that helped to establish long-range relationships between
openaire   +2 more sources

Next-Generation Sequencing

Current Pharmaceutical Design, 2019
Background: With the outbreak of high throughput next-generation sequencing (NGS), the biological research of drug discovery has been directed towards the oncology and infectious disease therapeutic areas, with extensive use in biopharmaceutical development and vaccine production.Method: In this review, an effort was made to address the basic ...
Tripathi, Pooja, Singh, Jyotsna, Lal, Jonathan A., Tripathi, Vijay   +3 more
openaire   +2 more sources

Next-generation sequencing-by-hybridization

Nature Biotechnology, 2008
A new hybridization-based technology offers advantages in sequencing genomes for which a reference genome exists.
openaire   +2 more sources

Metagenomics Using Next-Generation Sequencing

2014
Traditionally, microbial genome sequencing has been restricted to the small number of species that can be grown in pure culture. The progressive development of culture-independent methods over the last 15 years now allows researchers to sequence microbial communities directly from environmental samples.
Bragg,Lauren, Tyson, Gene W.
openaire   +5 more sources

Single-cell proteomics enabled by next-generation sequencing or mass spectrometry

Nature Methods, 2023
H. Bennett, William D. Stephenson, Christopher M. Rose, S. Darmanis   +3 more
semanticscholar   +1 more source

Next‐generation sequencing and the cytopathologist

Cancer Cytopathology, 2014
Catherine I, Dumur, Adele O, Kraft
openaire   +2 more sources

[Next generation sequencing].

Revue medicale de Bruxelles, 2018
Fine needle aspiration is the gold standard method to differentiate benign thyroid nodules from malignant. However, for 15 to 30% of the cases the cytological diagnosis is indeterminate, leading to surgery. Integration of new molecular markers is opening new perspectives in order to increase the diagnostic precision of thyroid nodules with an ...
M, Le Mercier, N, D'Haene, S, Rorive, C, Degand, N, De Nève, O, Blanchard, I, Salmon   +6 more
openaire   +1 more source