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The chemistry of next-generation sequencing
Nature Biotechnology, 2023The first large genome fully sequenced by next-generation sequencing (NGS) was that of a bacteriophage using sequencing by synthesis (SBS) as a paradigm. SBS in NGS is underpinned by 'reversible-terminator chemistry'. To grow from proof of concept to being both affordable and practical, SBS needed to overcome a series of challenges, each of which ...
Yamuna Krishnan, Raphaël Rodriguez
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Next-Generation Sequencing in Cancer
Journal of Maxillofacial and Oral Surgery, 2020In this article, we provide a gestalt idea about NGS technologies and their applications in cancer research and molecular diagnosis.Next-generation sequencing (NGS) advancements like DNA sequencing and RNA sequencing allow uncovering of genomic, transcriptomic, and epigenomic scenes of individual malignant growths.
S. Vinod Nair +3 more
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2016
Endometrial cancers are the most frequently diagnosed gynecological malignancy and were expected to be the seventh leading cause of cancer death among American women in 2015. The majority of endometrial cancers are of serous or endometrioid histology. Most human tumors, including endometrial tumors, are driven by the acquisition of pathogenic mutations
Matthieu, Le Gallo +2 more
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Endometrial cancers are the most frequently diagnosed gynecological malignancy and were expected to be the seventh leading cause of cancer death among American women in 2015. The majority of endometrial cancers are of serous or endometrioid histology. Most human tumors, including endometrial tumors, are driven by the acquisition of pathogenic mutations
Matthieu, Le Gallo +2 more
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Next Generation Sequencing: Transcriptomics
2021Fungal transcriptomics is a rising field which has gained attention in the last two decades. The recent democratization of high throughput next-generation sequencing (NGS) techniques for large-scale transcriptomic analysis provided the opportunity to explore transcriptomes at an unprecedented level of resolution.
Sillo, Fabiano
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Next-generation DNA sequencing
Nature Biotechnology, 2008DNA sequence represents a single format onto which a broad range of biological phenomena can be projected for high-throughput data collection. Over the past three years, massively parallel DNA sequencing platforms have become widely available, reducing the cost of DNA sequencing by over two orders of magnitude, and democratizing the field by putting ...
Jay, Shendure, Hanlee, Ji
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Regulation of Next Generation Sequencing
Journal of Law, Medicine & Ethics, 2014Since the first draft of the human genome was published in 2001, DNA sequencing technology has advanced at a remarkable pace. Launched in 1990, the Human Genome Project sought to sequence all three billion base pairs of the haploid human genome, an endeavor that took more than a decade and cost nearly three billion dollars.
Gail H, Javitt, Katherine Strong, Carner
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