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Next-generation sequencing [PDF]
Nature Reviews Drug Discovery, 2010 It has been widely appreciated that the genome sequence is shaping the future biomedical research. The genome sequence provides a general framework for assembling fragmentary DNA information into landscape of biological structure and function [1]. The rapid advances in DNA sequencing technology are revolutionizing biomedical research.
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The chemistry of next-generation sequencing
Nature Biotechnology, 2023The first large genome fully sequenced by next-generation sequencing (NGS) was that of a bacteriophage using sequencing by synthesis (SBS) as a paradigm. SBS in NGS is underpinned by 'reversible-terminator chemistry'. To grow from proof of concept to being both affordable and practical, SBS needed to overcome a series of challenges, each of which ...
Raphaël Rodriguez, Yamuna Krishnan
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Next-Generation Sequencing in Cancer
Journal of Maxillofacial and Oral Surgery, 2020In this article, we provide a gestalt idea about NGS technologies and their applications in cancer research and molecular diagnosis.Next-generation sequencing (NGS) advancements like DNA sequencing and RNA sequencing allow uncovering of genomic, transcriptomic, and epigenomic scenes of individual malignant growths.
S. Vinod Nair +3 more
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Next-generation sequencing of the next generation
Nature Reviews Genetics, 2010Darren J Burgess
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Next Generation Sequencing: Transcriptomics
2021Fungal transcriptomics is a rising field which has gained attention in the last two decades. The recent democratization of high throughput next-generation sequencing (NGS) techniques for large-scale transcriptomic analysis provided the opportunity to explore transcriptomes at an unprecedented level of resolution.
Sillo, Fabiano
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