Results 251 to 260 of about 5,172,921 (307)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Identification of the Novel HLA-DRB1*04:01:26 Allele by Next-Generation Sequencing. [PDF]

HLA
Harfouch E, Letoriellec E, Pare B, Chamillard X, Croisille L.   +4 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Identification of the Novel HLA-E*01:157 Allele by Next-Generation Sequencing. [PDF]

HLA
Dong L, He Y, Pi W, Chen N, Zhu F.
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Identification of the Novel HLA-A*68:346 Allele in a Brazilian Individual by Next-Generation Sequencing. [PDF]

HLA
Machado EFG, Linhares JA, Dugonski ME, Cazarote HB, Von Glehn CQC.   +4 more
europepmc   +1 more source

Identification of the Novel HLA-C*03:760 Allele by Next-Generation Sequencing. [PDF]

HLA
Du Z, Sudario MEA, Cussen K, Elrefaei M.
europepmc   +1 more source

Identification of the Novel HLA-DRB1*15:237 Allele by Next-Generation Sequencing. [PDF]

HLA
Wu Q, Chen N, Pi W, Tao S, Zhu F.
europepmc   +1 more source

Characterisation of the Novel HLA-DQB1*06:563N Allele by Next Generation Sequencing. [PDF]

HLA
Lion J, Dollerschell M, Bartczak S, Desoutter J, Guillaume N.   +4 more
europepmc   +1 more source

Six Novel HLA-DQB1*05 Intronic Variants Identified by Next-Generation Sequencing. [PDF]

HLA
Marin Rubio LA, Ontañon J.
europepmc   +1 more source