Results 231 to 240 of about 523,633 (260)
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Next-Generation Sequencing Platforms
Annual Review of Analytical Chemistry, 2013Automated DNA sequencing instruments embody an elegant interplay among chemistry, engineering, software, and molecular biology and have built upon Sanger's founding discovery of dideoxynucleotide sequencing to perform once-unfathomable tasks. Combined with innovative physical mapping approaches that helped to establish long-range relationships between
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Sequencing the next generation of glioblastomas
Critical Reviews in Clinical Laboratory Sciences, 2018The most aggressive brain malignancy, glioblastoma, accounts for 60-70% of all gliomas and is uniformly fatal. According to the molecular signature, glioblastoma is divided into four subtypes (proneural, neural, classical, and mesenchymal), each with its own genetic background.
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Current Pharmaceutical Design, 2019
Background: With the outbreak of high throughput next-generation sequencing (NGS), the biological research of drug discovery has been directed towards the oncology and infectious disease therapeutic areas, with extensive use in biopharmaceutical development and vaccine production.Method: In this review, an effort was made to address the basic ...
Tripathi, Pooja +3 more
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Background: With the outbreak of high throughput next-generation sequencing (NGS), the biological research of drug discovery has been directed towards the oncology and infectious disease therapeutic areas, with extensive use in biopharmaceutical development and vaccine production.Method: In this review, an effort was made to address the basic ...
Tripathi, Pooja +3 more
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Next-generation sequencing-by-hybridization
Nature Biotechnology, 2008A new hybridization-based technology offers advantages in sequencing genomes for which a reference genome exists.
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Metagenomics Using Next-Generation Sequencing
2014Traditionally, microbial genome sequencing has been restricted to the small number of species that can be grown in pure culture. The progressive development of culture-independent methods over the last 15 years now allows researchers to sequence microbial communities directly from environmental samples.
Bragg,Lauren, Tyson, Gene W.
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Next‐generation sequencing and the cytopathologist
Cancer Cytopathology, 2014Catherine I, Dumur, Adele O, Kraft
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Revue medicale de Bruxelles, 2018
Fine needle aspiration is the gold standard method to differentiate benign thyroid nodules from malignant. However, for 15 to 30% of the cases the cytological diagnosis is indeterminate, leading to surgery. Integration of new molecular markers is opening new perspectives in order to increase the diagnostic precision of thyroid nodules with an ...
M, Le Mercier +6 more
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Fine needle aspiration is the gold standard method to differentiate benign thyroid nodules from malignant. However, for 15 to 30% of the cases the cytological diagnosis is indeterminate, leading to surgery. Integration of new molecular markers is opening new perspectives in order to increase the diagnostic precision of thyroid nodules with an ...
M, Le Mercier +6 more
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Primer: Sequencing—the next generation
Nature Methods, 2007Nicole, Rusk, Veronique, Kiermer
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Clinical Metagenomic Next-Generation Sequencing for Pathogen Detection
Annual Review of Pathology: Mechanisms of Disease, 2019Wei Gu, Steve Miller, Charles Y Chiu
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