Results 231 to 240 of about 978,334 (297)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Rapid diagnostic value of next-generation sequencing-based technologies in childhood pneumonia. [PDF]

Front Pediatr
Chen Y, Zhu X, Fang F, Ma K, Zhang Y, Liu H.   +5 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Next Generation Sequencing of Classical Swine Fever Virus [PDF]

, 2015
Rasmussen, Thomas Bruun
core  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

A genomic approach for accurate identification of closely related species with next-generation sequencing samples. [PDF]

Sci Rep
Dain Marzouka NA, Al-Aamri A, Alshamsi F, Khalili M, Chehadeh SEH, Mohamed MS, Eltahir YM, Koliyan R, Abdelhalim MM, Attia A, Mousa M, Tay G, Alsafar H.   +12 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Antimicrobial use on <i>Campylobacter</i> revealed by next-generation sequencing in patients with common variable immunodeficiency. [PDF]

Front Microbiol
Jehanne Q, Conrad A, Josserand RN, Benech N, Schatz PM, Bénéjat L, Ducournau A, Aptel J, Martin M, Jauvain M, Dauwalder O, Lehours P.   +11 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Generic Protocols for the Analytical Validation of Next-Generation Sequencing-Based Circulating Tumor DNA Assays, Version 2.0. [PDF]

JCO Precis Oncol
Silvestro A, Baden J, Billings K, Bramlett K, Corner A, Danek T, Deras I, Dickey J, Godsey JH, Guan L, Hutchinson T, Johann DJ, Lee JSH, Lin CJ, Lococo JS, Lopez Ramos D, Richardson AO, Stetson D, Wenz P, Leiman LC.   +19 more
europepmc   +1 more source