Results 201 to 210 of about 270,662 (312)

The Prolonged Activation of the p65 Subunit of the NF-Kappa-B Nuclear Factor Sustains the Persistent Effect of Advanced Glycation End Products on Inflammatory Sensitization in Macrophages. [PDF]

Int J Mol Sci
Assis SIS, Amendola LS, Okamoto MM, Ferreira GDS, Iborra RT, Santos DR, Santana MFM, Santana KG, Correa-Giannella ML, Barbeiro DF, Soriano FG, Machado UF, Passarelli M.   +12 more
europepmc   +1 more source

Pentoxifylline Sensitizes Cisplatin-Resistant Human Cervical Cancer Cells to Cisplatin Treatment: Involvement of Mitochondrial and NF-Kappa B Pathways. [PDF]

Front Oncol, 2020
Bravo-Cuellar A, Ortiz-Lazareno PC, Sierra-Díaz E, Solorzano-Ibarra F, Méndez-Clemente AS, Aguilar-Lemarroy A, Jave-Suárez LF, Ruiz Velazco-Niño É, Hernández-Flores G.   +8 more
europepmc   +1 more source

Human coronary artery organ‐chip with circulating immune cells recapitulates anti‐inflammatory effect of pulsatile wall strain

Interdisciplinary Medicine, EarlyView.
A fully characterised organ‐on‐a‐chip model of the human coronary artery with endothelial and smooth muscle cells, plus circulating immune cells, created on the Emulate platform. The model successfully recapitulates the physiological effects of pulsatile vessel dilation on cell morphology and the localised inflammatory susceptibility to TNF‐α ...
Yu Hou, Georgios Ziakas, Tim Hopkins, Wen Wang, Hazel R. C. Screen, Martin M. Knight   +5 more
wiley   +1 more source

Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway. [PDF]

Drug Des Devel Ther, 2020
Liao Y, Tan RZ, Li JC, Liu TT, Zhong X, Yan Y, Yang JK, Lin X, Fan JM, Wang L.   +9 more
europepmc   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Occupational Exposure to Factory‐Derived Particulate Matter 2.5 Induces Cutaneous Toxicity in Workers and HaCaT Keratinocytes Through Oxidative Stress and Inflammation

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate the toxicological effects of occupational exposure to factory‐derived particulate matter (PM2.5) on human skin, emphasizing its role as a potential target organ of environmental toxicants. An epidemiological survey comparing factory and nonfactory workers was conducted by assessing their skin elasticity and color ...
Miku Tanaka, Masayuki Takaishi, Iroha Okuda, Toshiki Fujimoto, Mayumi Tsuji, Yuri Okano, Yasuhiro Ishihara, Maori Kono   +7 more
wiley   +1 more source

A hMTR4-PDIA3P1-miR-125/124-TRAF6 Regulatory Axis and Its Function in NF kappa B Signaling and Chemoresistance. [PDF]

Hepatology, 2020
Xie C, Zhang LZ, Chen ZL, Zhong WJ, Fang JH, Zhu Y, Xiao MH, Guo ZW, Zhao N, He X, Zhuang SM.   +10 more
europepmc   +1 more source

Immunomodulatory and Cytotoxic Properties of Enniatin B1 in Porcine Alveolar Macrophages

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study investigates the immunomodulatory effects of Enniatin B1 (ENNB1), an emerging mycotoxin, on porcine alveolar macrophages (PAMs), a species‐specific model relevant to human innate immunity. PAMs were exposed to increasing ENNB1 concentrations (0.5–6 μM) over 6, 24, and 48 h.
Sara Frazzini, Francesca Caloni, Paola Fossati, Giancarlo Ruffo, Luciana Rossi   +4 more
wiley   +1 more source