Nf-kappa b p52 subunit - Open Access .click

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TNFSF14/LIGHT, a Non-Canonical NF-κB Stimulus, Induces the HIF Pathway [PDF]

Cells, 2018
Non-canonical NF-κB signalling plays important roles in the development and function of the immune system but it also is deregulated in a number of inflammatory diseases.
Laura D’Ignazio, Michael Batie, Sonia Rocha +2 more
doaj +5 more sources

Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3 [PDF]

Oncogene, 2000
Members of the NF-kappa B/Rel transcription factor family have been shown recently to be required for cellular transformation by oncogenic Ras and by other oncoproteins and to suppress transformation-associated apoptosis. Furthermore, NF-kappa B has been shown to be activated by several oncoproteins including HER2/Neu, a receptor tyrosine kinase often ...
Guttridge, Denis C. +3 more
openaire +5 more sources

Inflammation as a Possible Trigger for Mitoxantrone-Induced Cardiotoxicity: An In Vivo Study in Adult and Infant Mice

Pharmaceuticals, 2021
Mitoxantrone (MTX) is a pharmaceutical drug used in the treatment of several cancers and refractory multiple sclerosis (MS). Despite its therapeutic value, adverse effects may be severe, namely the frequently reported cardiotoxicity, whose mechanisms ...
Ana Reis-Mendes +11 more
doaj +1 more source

Role of Inflammation and Redox Status on Doxorubicin-Induced Cardiotoxicity in Infant and Adult CD-1 Male Mice

Biomolecules, 2021
Doxorubicin (DOX) is a topoisomerase II inhibitor commonly used in the treatment of several types of cancer. Despite its efficacy, DOX can potentially cause fatal adverse effects, like cardiotoxicity. This work aimed to assess the role of inflammation in
Ana Reis-Mendes +9 more
doaj +1 more source

CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-κB subunits onIL-8andBcl-xLgene promoters [PDF]

Proceedings of the National Academy of Sciences, 2004
CD28 is one of the most important costimulatory receptors necessary for full T lymphocyte activation. The CD28 receptor can enhance T cell antigen receptor (TCR) signals, as well as deliver independent signals. Indeed, CD28 engagement by B7 can generate TCR-independent signals leading to IκB kinase and NF-κB activation. Here we demonstrate that the TCR-
MARINARI B. +4 more
openaire +6 more sources

Extracellular Tissue Transglutaminase Activates Noncanonical NF-κB Signaling and Promotes Metastasis in Ovarian Cancer

Neoplasia: An International Journal for Oncology Research, 2013
Tissue transglutaminase (TG2) is a multifunctional protein that binds to fibronectin and exerts protein transamidating activity in the presence of Ca2+.
Bakhtiyor Yakubov +5 more
doaj +1 more source

Novel Heterozygous Mutation in NFKB2 Is Associated With Early Onset CVID and a Functional Defect in NK Cells Complicated by Disseminated CMV Infection and Severe Nephrotic Syndrome

Frontiers in Pediatrics, 2019
Nuclear factor kappa-B subunit 2 (NF-κB2/p100/p52), encoded by NFKB2 (MIM: 164012) belongs to the NF-κB family of transcription factors that play a critical role in inflammation, immunity, cell proliferation, differentiation and survival.
Alejandra Aird +19 more
doaj +1 more source

Nuclear Factor NF-kappa-B p52 Subunit [PDF]

, 2020
openaire +1 more source

Triptolide combined with arsenic trioxide induces apoptosis of myelodysplastic syndrome cells by inhibiting the NF-κB signaling pathway. [PDF]

Medicine (Baltimore)
Sheng L +6 more
europepmc +1 more source

Canonical and noncanonical NF-κB signaling in uveal melanoma: mechanisms, microenvironment, and therapeutic modulation. [PDF]

Med Hypothesis Discov Innov Ophthalmol
Jalali S +6 more
europepmc +1 more source

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