Results 1 to 10 of about 36,830 (233)

The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA

EMBO Reports
The protein interactome of p65/RELA, the most active subunit of the transcription factor (TF) NF-κB, has not been previously determined in living cells.
Lisa Leib, Jana Juli, Liane Jurida, Christin Mayr-Buro, Jasmin Priester, Hendrik Weiser, Stefanie Wirth, Simon Hanel, Daniel Heylmann, Axel Weber, M Lienhard Schmitz, Argyris Papantonis, Marek Bartkuhn, Jochen Wilhelm, Uwe Linne, Johanna Meier-Soelch, Michael Kracht   +16 more
doaj   +7 more sources

Yangonin Blocks Tumor Necrosis Factor-α–Induced Nuclear Factor-κB–Dependent Transcription by Inhibiting the Transactivation Potential of the RelA/p65 Subunit

Journal of Pharmacological Sciences, 2012
The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, and apoptosis. In our search for NF-κB inhibitors from natural resources, we identified yangonin from Piper methysticum as an ...
Juan Ma, He Liang, Hong Ri Jin, Nguyen Tien Dat, Shan Yu Zhang, Ying Zi Jiang, Ji Xing Nan, Donghao Li, Xue Wu, Jung Joon Lee, Xuejun Jin   +10 more
doaj   +7 more sources

Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-κB.

PLoS ONE, 2012
Considerable evidence supports the prediction that CD25 is directly regulated by the forkhead transcription factor FOXP3. However, given that CD25 is normally upregulated in activated T cells, regardless of whether they express FOXP3, this issue has ...
Cristina Camperio, Silvana Caristi, Giorgia Fanelli, Marzia Soligo, Paola Del Porto, Enza Piccolella   +5 more
doaj   +5 more sources

Modulation of Gene Expression Regulated by the Transcription Factor NF-κB/RelA [PDF]

Journal of Biological Chemistry, 2014
Modulators (Ms) are proteins that modify the activity of transcription factors (TFs) and influence expression of their target genes (TGs). To discover modulators of NF-κB/RelA, we first identified 365 NF-κB/RelA-binding proteins using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Xueling Li, Yingxin Zhao, Bing Tian
exaly   +3 more sources

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability [PDF]

Frontiers in Immunology, 2019
Regulatory T cells (Tregs) play a major role in immune homeostasis and in the prevention of autoimmune diseases. It has been shown that c-Rel is critical in Treg thymic differentiation, but little is known on the role of NF-κB on mature Treg biology.
Emilie Ronin, Martina Lubrano di Ricco, Romain Vallion, Jordane Divoux, Ho-Keun Kwon, Sylvie Grégoire, Davi Collares, Angéline Rouers, Véronique Baud, Christophe Benoist, Benoit L. Salomon   +10 more
doaj   +4 more sources

Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-κB-driven transcription. [PDF]

PLoS Biology, 2013
NF-κB plays a vital role in cellular immune and inflammatory response, survival, and proliferation by regulating the transcription of various genes involved in these processes.
Sulakshana P Mukherjee, Marcelo Behar, Harry A Birnbaum, Alexander Hoffmann, Peter E Wright, Gourisankar Ghosh   +5 more
doaj   +3 more sources

Epigenetic context defines the transcriptional activity of canonical and noncanonical NF-κB signaling in pancreatic cancer [PDF]

Cell Death Discovery
NF-κB signaling can be subdivided into canonical and noncanonical pathways, culminating in the transcriptional activity of RELA and RELB, respectively. However, the upstream signals that activate these transcription factors and their specific regulatory ...
Joana E. Aggrey-Fynn, Joshua Busch, Dominik Saul, Ashish Rajput, Kerstin Willecke, Meghana Manjunath, Nicole Klimt, Kothai Rajendran, Nadine Schacherer, Wanwan Ge, Julia Thiel, Amro Abdelrahman, Mark J. Truty, Meng Dong, Steven A. Johnsen   +14 more
doaj   +2 more sources

The NF-κB transcription factor RelA directs mucosal-associated invariant T-cell development. [PDF]

Immunol Cell Biol
Abstract Mucosal‐associated invariant T (MAIT) cells are characterized by rapid responses to nonpeptide antigens via invariant T‐cell receptors (TCR), and expression of an “effector‐like” T‐cell phenotype. The transcription factor promyelocytic leukemia zinc finger (PLZF) is crucial for defining the function of MAIT cells and other ...
Fulford TS, Koay HF, Grumont R, Johnson DN, Scheer S, Nel HJ, Thomas R, Mak JY, Fairlie DP, Teh CE, Gray DH, Bryant VL, Zaph C, O'Reilly LA, Gerondakis S, Godfrey DI.   +15 more
europepmc   +4 more sources

Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-κB have a malignantly transformed phenotype [PDF]

Oncogene, 2002
The RelA transcription factor is part of dimeric complexes, most commonly either p50-RelA (NF-kappaB) heterodimers or RelA homodimers, that control a variety of cellular processes. Immortalized embryonic fibroblasts established from rela knockout mice have previously been shown to be more sensitive to apoptosis induced by tumor necrosis factor (TNF ...
Thomas D Gilmore, Gilmore Thomas D
exaly   +7 more sources

cJun-assisted loading of RelA DNA-binding promotes synergistic lung epithelial antimicrobial responses [PDF]

iScience
Summary: Lower respiratory tract infections remain a leading cause of death worldwide, highlighting the need for host-directed therapies. We previously identified an inhaled immunostimulatory combination of Pam2CSK4 (Pam2) and CpG oligodeoxynucleotide ...
Jezreel Pantaleón García, Keerthi Bhoda, Madeleine Burch-Eapen, Raquel Alonso Becerra, Paris Rodríguez Carstens, Daniela Covarrubias López, Jania Foncerrada Lizaola, Vikram V. Kulkarni, Jose Martinez, III, Yongxing Wang, Scott E. Evans   +10 more
doaj   +2 more sources