Results 1 to 10 of about 36,472 (203)

Forkhead Transcription Factor FOXP3 Upregulates CD25 Expression through Cooperation with RelA/NF-κB

PLoS ONE, 2012
Considerable evidence supports the prediction that CD25 is directly regulated by the forkhead transcription factor FOXP3. However, given that CD25 is normally upregulated in activated T cells, regardless of whether they express FOXP3, this issue has ...
Marzia Soligo, Giorgia Fanelli, Paola Del Porto   +2 more
exaly   +6 more sources

The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA

EMBO Reports
The protein interactome of p65/RELA, the most active subunit of the transcription factor (TF) NF-κB, has not been previously determined in living cells.
Argyris Papantonis, Axel Weber, Uwe Linné   +2 more
exaly   +5 more sources

Analysis of the RelA:CBP/p300 Interaction Reveals Its Involvement in NF-κB-Driven Transcription [PDF]

PLoS Biology, 2013
NF-κB plays a vital role in cellular immune and inflammatory response, survival, and proliferation by regulating the transcription of various genes involved in these processes.
Gourisankar Ghosh, Peter Wright, Alexander Hoffmann   +2 more
exaly   +2 more sources

Epigenetic context defines the transcriptional activity of canonical and noncanonical NF-κB signaling in pancreatic cancer [PDF]

Cell Death Discovery
NF-κB signaling can be subdivided into canonical and noncanonical pathways, culminating in the transcriptional activity of RELA and RELB, respectively. However, the upstream signals that activate these transcription factors and their specific regulatory ...
Joana E. Aggrey-Fynn, Joshua Busch, Dominik Saul, Ashish Rajput, Kerstin Willecke, Meghana Manjunath, Nicole Klimt, Kothai Rajendran, Nadine Schacherer, Wanwan Ge, Julia Thiel, Amro Abdelrahman, Mark J. Truty, Meng Dong, Steven A. Johnsen   +14 more
doaj   +2 more sources

cJun-assisted loading of RelA DNA-binding promotes synergistic lung epithelial antimicrobial responses [PDF]

iScience
Summary: Lower respiratory tract infections remain a leading cause of death worldwide, highlighting the need for host-directed therapies. We previously identified an inhaled immunostimulatory combination of Pam2CSK4 (Pam2) and CpG oligodeoxynucleotide ...
Jezreel Pantaleón García, Keerthi Bhoda, Madeleine Burch-Eapen, Raquel Alonso Becerra, Paris Rodríguez Carstens, Daniela Covarrubias López, Jania Foncerrada Lizaola, Vikram V. Kulkarni, Jose Martinez, III, Yongxing Wang, Scott E. Evans   +10 more
doaj   +2 more sources

SOX4 and RELA Function as Transcriptional Partners to Regulate the Expression of TNF- Responsive Genes in Fibroblast-Like Synoviocytes

Frontiers in Immunology, 2022
SOX4 belongs to the group C of the SOX transcription factor family. It is a critical mediator of tumor necrosis factor alpha (TNF)-induced transformation of fibroblast-like s-ynoviocytes (FLS) in arthritis.
Kyle Jones, Kyle Jones, Sergio Ramirez-Perez, Sergio Ramirez-Perez, Sean Niu, Sean Niu, Umesh Gangishetti, Umesh Gangishetti, Hicham Drissi, Hicham Drissi, Hicham Drissi, Pallavi Bhattaram, Pallavi Bhattaram   +12 more
doaj   +1 more source

RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer

Scientific Reports, 2022
CD271 (also referred to as nerve growth factor receptor or p75NTR) is expressed on cancer stem cells in hypopharyngeal cancer (HPC) and regulates cell proliferation.
Akira Nakazato, Mai Mochizuki, Rie Shibuya-Takahashi, Haruna Fujimori, Keitaro Fujii, Satoshi Saijoh, Shinkichi Morita, Tomoko Yamazaki, Takayuki Imai, Ikuro Sato, Kennichi Satoh, Kazunori Yamaguchi, Kazuo Sugamura, Jun Yasuda, Kazuto Matsuura, Hideo Shojaku, Yukinori Asada, Keiichi Tamai   +17 more
doaj   +1 more source

C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation

Acta Neuropathologica Communications, 2021
Recurrent C11orf95-RELA fusions (RELA FUS ) are the hallmark of supratentorial ependymomas. The presence of RELA as the fusion partner indicates a close association of aberrant NF-κB activity with tumorigenesis.
Tatsuya Ozawa, Syuzo Kaneko, Frank Szulzewsky, Zhiwei Qiao, Mutsumi Takadera, Yoshitaka Narita, Tadashi Kondo, Eric C. Holland, Ryuji Hamamoto, Koichi Ichimura   +9 more
doaj   +1 more source

Identification of super-enhancer-associated transcription factors regulating glucose metabolism in poorly differentiated thyroid carcinoma

Genetics and Molecular Biology, 2022
This study aimed to uncover transcription factors that regulate super-enhancers involved in glucose metabolism reprogramming in poorly differentiated thyroid carcinoma (PDTC).
Kun Liu, Yongrui Du, Hui Li, Xuexia Lin
doaj   +1 more source

Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice

Scientific Reports, 2022
The fusion protein of uncharacterised zinc finger translocation associated (ZFTA) and effector transcription factor of tumorigenic NF-κB signalling, RELA (ZFTA-RELA), is expressed in more than two-thirds of supratentorial ependymoma (ST-EPN-RELA), but ...
Vicente Herranz-Pérez, Jin Nakatani, Masaki Ishii, Toshiaki Katada, Jose Manuel García-Verdugo, Shinya Ohata   +5 more
doaj   +1 more source