Results 11 to 20 of about 36,830 (233)

The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer [PDF]

Frontiers in Immunology
CD8+ T cells are critical mediators of pathogen clearance and anti-tumor immunity. Although signaling pathways leading to the activation of NF-κB transcription factors have crucial functions in the regulation of immune responses, the CD8+ T cell ...
Allison Voisin, Maud Plaschka, Maud Plaschka, Marlène Perrin-Niquet, Julie Twardowski, Insaf Boutemine, Baptiste Eluard, Guilhem Lalle, Pierre Stéphan, Khaled Bouherrou, Laurie Tonon, Laurie Tonon, Roxane Pommier, Roxane Pommier, Anthony Ferrari, Anthony Ferrari, Ulf Klein, Mélanie Wencker, Véronique Baud, Philippe A. Cassier, Philippe A. Cassier, Yenkel Grinberg-Bleyer   +21 more
doaj   +7 more sources

RelA and RelB Transcription Factors in Distinct Thymocyte Populations Control Lymphotoxin-Dependent Interleukin-17 Production in γδ T Cells [PDF]

Immunity, 2011
The NF-κB transcription factor regulates numerous immune responses but its contribution to interleukin-17 (IL-17) production by T cells is largely unknown. Here, we report that IL-17, but not interferon-γ (IFN-γ), production by γδ T cells required the NF-κB family members RelA and RelB as well as the lymphotoxin-β-receptor (LTβR).
Marc Riemann, Roland M Schmid, Thomas Hehlgans   +2 more
exaly   +5 more sources

Dynamics of REL, RELA and IRF1 transcription factor expression in U937 macrophages after dioxin exposure

Вавиловский журнал генетики и селекции, 2017
The aryl hydrocarbon receptor (AhR), a ligand- activated transcription factor, participates in a wide range of critical cellular events in response to endogenous signals or xenobiotic chemicals. 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) is one of the
E. V. Kashina, D. Y. Oshchepkov, E. V. Antontseva, M. Y. Shamanina, D. P. Furman, V. A. Mordvinov   +5 more
doaj   +4 more sources

DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor κB are not correlated [PDF]

Journal of Biological Chemistry, 2017
The nuclear factor κB (NF-κB) transcription factor family regulates genes involved in cell proliferation and inflammation. The promoters of these genes often contain NF-κB-binding sites (κB sites) arranged in tandem. How NF-κB activates transcription through these multiple sites is incompletely understood.
Maria Carmen Mulero, De-Bin Huang, H. Thien Nguyen, Vivien Ya-Fan Wang, Yidan Li, Tapan Biswas, Gourisankar Ghosh   +6 more
openaire   +6 more sources

Differential RelA- and RelB-dependent gene transcription in LTβR-stimulated mouse embryonic fibroblasts [PDF]

BMC Genomics, 2008
Background Lymphotoxin signaling via the lymphotoxin-β receptor (LTβR) has been implicated in biological processes ranging from development of secondary lymphoid organs, maintenance of spleen architecture, host defense against pathogens, autoimmunity ...
Yilmaz Z Buket, Albrecht Daniela, Radke Dörte, Lovas Agnes, Möller Ulrich, Habenicht Andreas JR, Weih Falk   +6 more
doaj   +2 more sources

Activation of Nuclear Factor-κB-dependent Transcription by Tumor Necrosis Factor-α Is Mediated through Phosphorylation of RelA/p65 on Serine 529 [PDF]

Journal of Biological Chemistry, 1998
Nuclear factor-κB (NF-κB) is an essential transcription factor in the control of expression of genes involved in immune and inflammatory responses. In unstimulated cells, NF-κB complexes are sequestered in the cytoplasm through interactions with IκBα and other IκB proteins.
D, Wang, A S, Baldwin
openaire   +4 more sources

NF-κB repression by PIAS3 mediated RelA SUMOylation. [PDF]

PLoS ONE, 2012
Negative regulation of the NF-κB transcription factor is essential for tissue homeostasis in response to stress and inflammation. NF-κB activity is regulated by a variety of biochemical mechanisms including phosphorylation, acetylation, and ...
Yuangang Liu, Rebecca Bridges, Aaron Wortham, Molly Kulesz-Martin   +3 more
doaj   +2 more sources

Interferon-β induction heterogeneity during KSHV infection is correlated to levels and activation of the transcription factors ATF2 and RelA, and not IRF3. [PDF]

PLoS Pathog
Careful regulation of type I interferons (IFN) like IFN-β is vital for balancing tissue damage and protection against infections. Heterogeneity in type I IFN expression among virally infected cells is a common phenomenon that may help limit IFN responses, but the source of this heterogeneity is poorly understood.
Kaku M, Gaglia MM.
europepmc   +3 more sources

P01.05 Overexpression of FAT1 gene in GBM is regulated by transcription factor NFkB (RelA) [PDF]

Neuro-Oncology, 2017
Introduction: Glioblastoma (GBM) is the most common and aggressive form of primary brain cancer with high tendency for local invasiveness. Hypoxia is a critical feature of glioblastoma, promoting tumor invasiveness via HIF1α.
K. Chosdol, C. Srivastava, K. Irshad, H. Srinivas, Y. Gupta, C. Sarkar, A. Suri, D. K. Gupta, P. Chattopadhyay, S. Sinha   +9 more
openaire   +2 more sources

Differential DNA sequence specificity and regulation of HIV-1 enhancer activity by cRel-RelA transcription factor.

Journal of Biological Chemistry, 1994
The cRel-RelA and NF-kappa B (p50-RelA) transcription factors bind to a kappa B-like sequence termed Rel-related proteins binding element localized in the regulatory region of the human urokinase plasminogen activator (uPA) gene. This sequence is highly conserved in murine and porcine uPA genes where it retained the ability to associate with cRel-RelA.
Francesco Blasi, Luisa Guerrini, S K Hansen   +2 more
openaire   +4 more sources