Results 11 to 20 of about 36,472 (203)

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability [PDF]

Frontiers in Immunology, 2019
Regulatory T cells (Tregs) play a major role in immune homeostasis and in the prevention of autoimmune diseases. It has been shown that c-Rel is critical in Treg thymic differentiation, but little is known on the role of NF-κB on mature Treg biology.
Emilie Ronin, Martina Lubrano di Ricco, Romain Vallion, Jordane Divoux, Ho-Keun Kwon, Sylvie Grégoire, Davi Collares, Angéline Rouers, Véronique Baud, Christophe Benoist, Benoit L. Salomon   +10 more
doaj   +4 more sources

The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer

Frontiers in Immunology
CD8+ T cells are critical mediators of pathogen clearance and anti-tumor immunity. Although signaling pathways leading to the activation of NF-κB transcription factors have crucial functions in the regulation of immune responses, the CD8+ T cell ...
Allison Voisin, Maud Plaschka, Maud Plaschka, Marlène Perrin-Niquet, Julie Twardowski, Insaf Boutemine, Baptiste Eluard, Guilhem Lalle, Pierre Stéphan, Khaled Bouherrou, Laurie Tonon, Laurie Tonon, Roxane Pommier, Roxane Pommier, Anthony Ferrari, Anthony Ferrari, Ulf Klein, Mélanie Wencker, Véronique Baud, Philippe A. Cassier, Philippe A. Cassier, Yenkel Grinberg-Bleyer   +21 more
doaj   +6 more sources

Dynamics of REL, RELA and IRF1 transcription factor expression in U937 macrophages after dioxin exposure

Вавиловский журнал генетики и селекции, 2017
The aryl hydrocarbon receptor (AhR), a ligand- activated transcription factor, participates in a wide range of critical cellular events in response to endogenous signals or xenobiotic chemicals. 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) is one of the
E. V. Kashina, D. Y. Oshchepkov, E. V. Antontseva, M. Y. Shamanina, D. P. Furman, V. A. Mordvinov   +5 more
doaj   +3 more sources

Yangonin Blocks Tumor Necrosis Factor-α–Induced Nuclear Factor-κB–Dependent Transcription by Inhibiting the Transactivation Potential of the RelA/p65 Subunit

Journal of Pharmacological Sciences, 2012
The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, and apoptosis. In our search for NF-κB inhibitors from natural resources, we identified yangonin from Piper methysticum as an ...
Juan Ma, He Liang, Hong Ri Jin, Nguyen Tien Dat, Shan Yu Zhang, Ying Zi Jiang, Ji Xing Nan, Donghao Li, Xue Wu, Jung Joon Lee, Xuejun Jin   +10 more
doaj   +4 more sources

The NF-κB transcription factor RelA directs mucosal-associated invariant T-cell development. [PDF]

Immunol Cell Biol
Abstract Mucosal‐associated invariant T (MAIT) cells are characterized by rapid responses to nonpeptide antigens via invariant T‐cell receptors (TCR), and expression of an “effector‐like” T‐cell phenotype. The transcription factor promyelocytic leukemia zinc finger (PLZF) is crucial for defining the function of MAIT cells and other ...
Fulford TS, Koay HF, Grumont R, Johnson DN, Scheer S, Nel HJ, Thomas R, Mak JY, Fairlie DP, Teh CE, Gray DH, Bryant VL, Zaph C, O'Reilly LA, Gerondakis S, Godfrey DI.   +15 more
europepmc   +5 more sources

BRCA1 Augments Transcription by the NF-κB Transcription Factor by Binding to the Rel Domain of the p65/RelA Subunit [PDF]

Journal of Biological Chemistry, 2003
BRCA1 is a tumor suppressor gene mutated in cases of hereditary breast and ovarian cancer. BRCA1 protein is involved in apoptosis and growth/tumor suppression. In this study, we present evidence that p65/RelA, one of the two subunits of the transcription factor NF-kappaB, binds to the BRCA1 protein.
Miriam, Benezra, Nathalie, Chevallier, Debra J, Morrison, Timothy K, MacLachlan, Wafik S, El-Deiry, Jonathan D, Licht   +5 more
openaire   +2 more sources

The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects [PDF]

Proceedings of the National Academy of Sciences, 1999
Individual Rel/NF-κB transcription factors, although dispensable for the development and maturation of most hemopoietic cells, are critical regulators of normal immune function. Redundancy among these proteins prompted us to examine the role of Rel and RelA in hemopoiesis by using mice that lack both subunits.
Grossmann, Mathis, Metcalf, Donald, Merryfull, Julie, Beg, Amer, Baltimore, David, Gerondakis, Steve   +5 more
openaire   +4 more sources

DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor κB are not correlated [PDF]

Journal of Biological Chemistry, 2017
The nuclear factor κB (NF-κB) transcription factor family regulates genes involved in cell proliferation and inflammation. The promoters of these genes often contain NF-κB-binding sites (κB sites) arranged in tandem. How NF-κB activates transcription through these multiple sites is incompletely understood.
Maria Carmen Mulero, De-Bin Huang, H. Thien Nguyen, Vivien Ya-Fan Wang, Yidan Li, Tapan Biswas, Gourisankar Ghosh   +6 more
openaire   +4 more sources

The Hippo effector YAP1 biochemically and functionally interacts with the nuclear factor‐kappa B/RELA transcription factor

The FASEB Journal, 2021
The transcriptional co‐activator YAP1 (yes‐associated protein 1) is a critical nuclear effector of the Hippo pathway. The Hippo pathway regulates cell growth, cell motility, cell migration, and carcinogenesis, but poorly defined mechanism. We investigated biochemical and functional interactions between YAP1 and the nuclear factor (NF)‐kappa B/RELA ...
Bekir Cinar, Elijah Said‐Bandy, Marwah Mathkour, Ava Boston, Abdulrahman Dwead, Carlos Moreno   +5 more
openaire   +1 more source

NF-κB repression by PIAS3 mediated RelA SUMOylation. [PDF]

PLoS ONE, 2012
Negative regulation of the NF-κB transcription factor is essential for tissue homeostasis in response to stress and inflammation. NF-κB activity is regulated by a variety of biochemical mechanisms including phosphorylation, acetylation, and ...
Yuangang Liu, Rebecca Bridges, Aaron Wortham, Molly Kulesz-Martin   +3 more
doaj   +1 more source