Results 31 to 40 of about 36,830 (233)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB [PDF]

Cancers, 2019
Regulation of Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)/Rel transcription factors (TFs) is extremely cell-type-specific owing to their ability to act disparately in the context of cellular homeostasis driven by cellular fate and the microenvironment.
Derya Kabacaoglu, Dietrich A. Ruess, Jiaoyu Ai, Hana Algül   +3 more
openaire   +3 more sources

RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke [PDF]

, 2009
The activation of transcription factor NF-kappaB is controlled by two main pathways: the classical canonical (RelA/p65-p50)- and the alternative noncanonical (RelB/p52)-NF-kappaB pathways.
Edirisinghe, Indika, Sime, Patricia J, Rajendrasozhan, Saravanan, Valvo, Samantha, McCabe Jr., Michael J, Bulger, Michael, Yao, Hongwei, Rahman, Irfan, Yang, Se-Ran, Li, Jian-Dong, Chung, Sangwoon, Fromm, George, Phipps, Richard P   +12 more
core   +1 more source

Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α [PDF]

, 2013
Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (IL1B ...
Unlu, Sebnem, Gillian M. Tannahill (440532), O’Neill Luke A., Kent Z. Q. Wang (440530), Kent Z. Q. Wang, Galson, Deborah L., Galson Deborah L., Luke A. O’Neill (440534), Tannahill Gillian M., Auron Philip E., O'Neill, LA, Adamik, Juraj, Su An-Jey A., Gillian M. Tannahill, Sebnem Unlu, Philip E. Auron, Unlu Sebnem, Gillian M Tannahill, Adamik, J, An-Jey A. Su, Yan, Chunhong, Auron, PE, Deborah L. Galson, Luke A. O’Neill, Luke A O'Neill, O’Neill, Luke A., Su, AJA, Tannahill, GM, An-Jey A. Su (440531), O\u27Neill, Luke A., Deborah L Galson, Wang, KZQ, An-Jey A Su, Kent Z Q Wang, Unlu, S, Sebnem Unlu (156119), Wang, Kent Z. Q., Juraj Adamik (440529), Galson, DL, Adamik Juraj, Philip E. Auron (440535), Philip E Auron, Wang Kent Z. Q., Su, An Jey A., Tannahill, Gillian M., Su, An-Jey A., Wang, Kent Z.Q., Deborah L. Galson (440533), Auron, Philip E., Juraj Adamik   +49 more
core   +1 more source

Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses

Biomedicines, 2022
The NFκB transcription factors are major regulators of innate immune responses, and NFκB signal pathway dysregulation is linked to inflammatory disease. Here, we utilised bone marrow-derived macrophages from the p65-DsRedxp/IκBα-eGFP transgenic strain to
Stamatia Papoutsopoulou, Lorna Morris, Andrew Bayliff, Thomas Mair, Hazel England, Massimiliano Stagi, François Bergey, Mohammad Tauqeer Alam, Raheleh Sheibani-Tezerji, Philip Rosenstiel, Werner Müller, Vitor A. P. Martins Dos Santos, Barry J. Campbell   +12 more
doaj   +1 more source

SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease [PDF]

, 2008
RATIONALE:Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging and antiinflammatory protein, is a metabolic NAD(+)-dependent protein ...
Rajendrasozhan, Saravanan, Kinnula, Vuokko L, Rahman, Irfan, Yang, Se-Ran   +3 more
core   +1 more source

Sequential and synchronized hypertonicity-induced activation of Rel-family transcription factors is required for osmoprotection in renal cells

Heliyon, 2018
NF-κB and TonEBP belong to the Rel-superfamily of transcription factors. Several specific stimuli, including hypertonicity which is a key factor for renal physiology, are able to activate them. It has been reported that, after hypertonic challenge, NF-κB
Cecilia I. Casali, Luciana C. Erjavec, María del Carmen Fernández-Tome   +2 more
doaj   +1 more source

Inferring Genome-Wide Functional Modulatory Network: A Case Study on NF-κB/RelA Transcription Factor [PDF]

Journal of Computational Biology, 2015
How different pathways lead to the activation of a specific transcription factor (TF) with specific effects is not fully understood. We model context-specific transcriptional regulation as a modulatory network: triplets composed of a TF, target gene, and modulator. Modulators usually affect the activity of a specific TF at the posttranscriptional level
Xueling Li, Min Zhu, Allan R. Brasier, Andrzej S. Kudlicki   +3 more
openaire   +2 more sources

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1.

PLoS Genetics, 2021
In mammals, the circadian clock coordinates cell physiological processes including inflammation. Recent studies suggested a crosstalk between these two pathways. However, the mechanism of how inflammation affects the clock is not well understood.
Yang Shen, Mehari Endale, Wei Wang, Andrew R Morris, Lauren J Francey, Rachel L Harold, David W Hammers, Zhiguang Huo, Carrie L Partch, John B Hogenesch, Zhao-Hui Wu, Andrew C Liu   +11 more
doaj   +1 more source

EPEN-05. TRANSCRIPTIONAL FACTOR-DIRECTED EPIGENETIC REGULATION IN CANCER NEUROSCIENCE OF ZFTA-RELA EPENDYMOMA

Neuro-Oncology, 2023
Abstract ZFTA-RELA (ZRFUS) ependymoma is a pediatric brain tumor with dismal 10-year progression free survival rates. Prior studies revealed low somatic mutation load in pediatric ependymoma compared to adult glioma, suggesting that developmental mechanisms play a key role during disease development.
Chen, Hsiao-Chi, McDonald, Malcolm, Varadharajan, Srinidhi, Sardar, Debosmita, Mack, Stephen C, Deneen, Benjamin   +5 more
openaire   +1 more source