Results 31 to 40 of about 36,472 (203)

Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1

Nature Communications, 2020
The nuclear factors κB (NF-κB) is a transcription factor involved in immune functions, inflammation, and cancer. Here, the authors show that the NF-κB factor RELA regulates splicing of target genes by recruiting DDX17 on chromatin upon expression of the ...
Lamya Ben Ameur, Paul Marie, Morgan Thenoz, Guillaume Giraud, Emmanuel Combe, Jean-Baptiste Claude, Sebastien Lemaire, Nicolas Fontrodona, Hélène Polveche, Marine Bastien, Antoine Gessain, Eric Wattel, Cyril F. Bourgeois, Didier Auboeuf, Franck Mortreux   +14 more
doaj   +1 more source

Interferon-β induction heterogeneity during KSHV infection is correlated to levels and activation of the transcription factors ATF2 and RelA, and not IRF3. [PDF]

PLoS Pathog
Careful regulation of type I interferons (IFN) like IFN-β is vital for balancing tissue damage and protection against infections. Heterogeneity in type I IFN expression among virally infected cells is a common phenomenon that may help limit IFN responses, but the source of this heterogeneity is poorly understood.
Kaku M, Gaglia MM.
europepmc   +4 more sources

Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

Nature Communications, 2016
Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults ...
Hiroshi Kobayashi, Song Ho Chang, Daisuke Mori, Shozo Itoh, Makoto Hirata, Yoko Hosaka, Yuki Taniguchi, Keita Okada, Yoshifumi Mori, Fumiko Yano, Ung-il Chung, Haruhiko Akiyama, Hiroshi Kawaguchi, Sakae Tanaka, Taku Saito   +14 more
doaj   +1 more source

Activation of Nuclear Factor-κB-dependent Transcription by Tumor Necrosis Factor-α Is Mediated through Phosphorylation of RelA/p65 on Serine 529 [PDF]

Journal of Biological Chemistry, 1998
Nuclear factor-κB (NF-κB) is an essential transcription factor in the control of expression of genes involved in immune and inflammatory responses. In unstimulated cells, NF-κB complexes are sequestered in the cytoplasm through interactions with IκBα and other IκB proteins.
D, Wang, A S, Baldwin
openaire   +2 more sources

Aggressive Supratentorial Ependymoma, Fusion-Positive with Extracranial Metastasis: A Case Report [PDF]

Journal of Pathology and Translational Medicine, 2017
Ependymoma is the third most common pediatric primary brain tumor. Ependymomas are categorized according to their locations and genetic abnormalities, and these two parameters are important prognostic factors for patient outcome.
Seong-Ik Kim, Yoojin Lee, Seung Ki Kim, Hyoung Jin Kang, Sung-Hye Park   +4 more
doaj   +1 more source

The cellular state determines the effect of melatonin on the survival of mixed cerebellar cell culture. [PDF]

PLoS ONE, 2014
The constitutive activation of nuclear factor-κB (NF-κB), a key transcription factor involved in neuroinflammation, is essential for the survival of neurons in situ and of cerebellar granule cells in culture.
Daiane Gil Franco, Regina P Markus
doaj   +1 more source

Differential RelA- and RelB-dependent gene transcription in LTβR-stimulated mouse embryonic fibroblasts

BMC Genomics, 2008
Background Lymphotoxin signaling via the lymphotoxin-β receptor (LTβR) has been implicated in biological processes ranging from development of secondary lymphoid organs, maintenance of spleen architecture, host defense against pathogens, autoimmunity ...
Yilmaz Z Buket, Albrecht Daniela, Radke Dörte, Lovas Agnes, Möller Ulrich, Habenicht Andreas JR, Weih Falk   +6 more
doaj   +1 more source

RelA Is a Component of the Nutritional Stress Activation Pathway of theBacillus subtilisTranscription Factor σ^B [PDF]

Journal of Bacteriology, 2003
ABSTRACTThe general stress regulon ofBacillus subtilisis induced by the activation of the σBtranscription factor. Activation of σBoccurs when one of two phosphatases (RsbU and RsbP), each responding to a unique type of stress, actuates a positive regulator of σBby dephosphorylation. Nutritional stress triggers the RsbP phosphatase.
Shuyu, Zhang, W G, Haldenwang
openaire   +2 more sources

Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production.

PLoS ONE, 2010
Human Immunodeficiency Virus-1 (HIV-1)-associated neurocognitive disorder (HAND) is likely neuroinflammatory in origin, believed to be triggered by inflammatory and oxidative stress responses to cytokines and HIV protein gene products such as the HIV ...
Michelle Kiebala, Oksana Polesskaya, Zhenqiang Yao, Seth W Perry, Sanjay B Maggirwar   +4 more
doaj   +1 more source

Involvement of RelA-Associated Inhibitor in Regulation of Trophoblast Differentiation via Interaction with Transcriptional Factor Specificity Protein-1 [PDF]

Endocrinology, 2007
Glucose transporter-1 (GLUT1), one of the key functional indicators of placental differentiation, has an important role in placental glucose transport. We previously showed that the protein levels of GLUT1 and nuclear transcription factor specificity protein-1 (Sp1) in rat choriocarcinoma cells (Rcho-1 cells) decreased during the differentiation of ...
Ryoko, Minekawa, Masahiro, Sakata, Yoko, Okamoto, Masami, Hayashi, Aki, Isobe, Takashi, Takeda, Toshiya, Yamamoto, Masayasu, Koyama, Masahide, Ohmichi, Keiichi, Tasaka, Kenichi, Imai, Takashi, Okamoto, Yuji, Murata   +12 more
openaire   +2 more sources