Results 51 to 60 of about 36,830 (233)
The cellular state determines the effect of melatonin on the survival of mixed cerebellar cell culture. [PDF]
PLoS ONE, 2014 The constitutive activation of nuclear factor-κB (NF-κB), a key transcription factor involved in neuroinflammation, is essential for the survival of neurons in situ and of cerebellar granule cells in culture.
Daiane Gil Franco, Regina P Markus
doaj +1 more source
Involvement of RelA-Associated Inhibitor in Regulation of Trophoblast Differentiation via Interaction with Transcriptional Factor Specificity Protein-1 [PDF]
Endocrinology, 2007 Glucose transporter-1 (GLUT1), one of the key functional indicators of placental differentiation, has an important role in placental glucose transport. We previously showed that the protein levels of GLUT1 and nuclear transcription factor specificity protein-1 (Sp1) in rat choriocarcinoma cells (Rcho-1 cells) decreased during the differentiation of ...
Ryoko, Minekawa +12 more
openaire +2 more sources
PLoS ONE, 2010 Human Immunodeficiency Virus-1 (HIV-1)-associated neurocognitive disorder (HAND) is likely neuroinflammatory in origin, believed to be triggered by inflammatory and oxidative stress responses to cytokines and HIV protein gene products such as the HIV ...
Michelle Kiebala +4 more
doaj +1 more source
Activation of RelA homodimers by tumour necrosis factor α: a possible transcriptional activator in human vascular endothelial cells [PDF]
Biochemical Journal, 2005 In vascular endothelial cells, cytokines induce genes that are expressed in inflammatory lesions partly through the activation of transcription factor NF-κB (nuclear factor-κB). Among the members of the NF-κB/rel protein family, homodimers of the RelA subunit of NF-κB can also function as strong transactivators when expressed in cells.
Nobuyuki, Marui +2 more
openaire +2 more sources
, 2016 RelA (NF-κB) is a transcription factor inducible by distinct stimuli in many different cell types. To find new cell type specific cofactors of NF-κB dependent transcription, we isolated RelA transcription activation domain binding proteins from the ...
Heather R. Owen (2674882) +4 more
core +2 more sources
The NF-κB subunit RelA/p65 is dispensable for successful liver regeneration after partial hepatectomy in mice. [PDF]
PLoS ONE, 2012 BACKGROUND: The transcription factor NF-κB consisting of the subunits RelA/p65 and p50 is known to be quickly activated after partial hepatectomy (PH), the functional relevance of which is still a matter of debate.
Marc Ringelhan +2 more
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Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks. [PDF]
PLoS Genetics, 2011 The sirtuin Sirt6 is a NAD-dependent histone deacetylase that is implicated in gene regulation and lifespan control. Sirt6 can interact with the stress-responsive transcription factor NF-κB and regulate some NF-κB target genes, but the full scope of ...
Tiara L A Kawahara +5 more
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, 2006 Brockmann-Gretza O, Kalinowski J. Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p) ppGpp synthase. BMC Genomics.
Brockmann-Gretza Olaf +5 more
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Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]
, 2012 Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A. +6 more
core +1 more source
PLoS ONE, 2022 Acyl-CoA synthetase 1 (ACSL1) is an enzyme that converts fatty acids to acyl-CoA-derivatives for lipid catabolism and lipid synthesis in general and can provide substrates for the production of mediators of inflammation in monocytes and macrophages ...
Prashanth Thevkar-Nagesh +12 more
doaj +1 more source