Results 41 to 50 of about 36,830 (233)

The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues

Cell Reports, 2017
After exiting the thymus, Foxp3+ regulatory T (Treg) cells undergo further differentiation in the periphery, resulting in the generation of mature, fully suppressive effector (e)Treg cells in a process dependent on TCR signaling and the transcription ...
Ajithkumar Vasanthakumar, Yang Liao, Peggy Teh, Maria F. Pascutti, Anna E. Oja, Alexandra L. Garnham, Renee Gloury, Jessica C. Tempany, Tom Sidwell, Eloy Cuadrado, Paul Tuijnenburg, Taco W. Kuijpers, Najoua Lalaoui, Lisa A. Mielke, Vanessa L. Bryant, Philip D. Hodgkin, John Silke, Gordon K. Smyth, Martijn A. Nolte, Wei Shi, Axel Kallies   +20 more
doaj   +1 more source

Nuclear factor-kB p65 (RelA) transcription factor is constitutively activated in human colorectal carcinoma tissue

World Journal of Gastroenterology, 2004
Activation of transcription factor nuclear factor-kappaB (NF-kappaB) has been shown to play a role in cell proliferation, apoptosis, cytokine production, and oncogenesis. The purpose of this study was to determine whether NF-kappaB was constitutively activated in human colorectal tumor tissues and, if so, to determine the role of NF-kappaB in ...
Liang-Liang, Yu, Hong-Gang, Yu, Jie-Ping, Yu, He-Sheng, Luo, Xi-Ming, Xu, Jun-Hua, Li   +5 more
openaire   +2 more sources

Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation.

PLoS Biology, 2018
Transcription factor nuclear factor kappa B (NF-κB) regulates cellular responses to environmental cues. Many stimuli induce NF-κB transiently, making time-dependent transcriptional outputs a fundamental feature of NF-κB activation.
Mingming Zhao, Jaimy Joy, Weiqiang Zhou, Supriyo De, William H Wood, Kevin G Becker, Hongkai Ji, Ranjan Sen   +7 more
doaj   +1 more source

An Expanded Interplay Network between NF-κB p65 (RelA) and E2F1 Transcription Factors: Roles in Physiology and Pathology

Cancers, 2022
Transcription Factors (TFs) are the main regulators of gene expression, controlling among others cell homeostasis, identity, and fate. TFs may either act synergistically or antagonistically on nearby regulatory elements and their interplay may activate or repress gene expression. The family of NF-κB TFs is among the most important TFs in the regulation
Spyros Foutadakis, Eugenia Roupakia, Panagiotis Liakopoulos, Petros Kolovos, Evangelos Kolettas   +4 more
openaire   +2 more sources

Recruitment of RelB to the Csf2 Promoter Enhances RelA-mediated Transcription of Granulocyte-Macrophage Colony-stimulating Factor [PDF]

Journal of Biological Chemistry, 2011
Tumor necrosis factor (TNF) induces expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) but lymphotoxin β (LTβ) does not. Here we report that priming of cells with agonistic LTβ receptor antibody synergistically enhanced TNF-induced GM-CSF expression.
Carl Y, Sasaki, Paritosh, Ghosh, Dan L, Longo   +2 more
openaire   +2 more sources

Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1

Nature Communications, 2020
The nuclear factors κB (NF-κB) is a transcription factor involved in immune functions, inflammation, and cancer. Here, the authors show that the NF-κB factor RELA regulates splicing of target genes by recruiting DDX17 on chromatin upon expression of the ...
Lamya Ben Ameur, Paul Marie, Morgan Thenoz, Guillaume Giraud, Emmanuel Combe, Jean-Baptiste Claude, Sebastien Lemaire, Nicolas Fontrodona, Hélène Polveche, Marine Bastien, Antoine Gessain, Eric Wattel, Cyril F. Bourgeois, Didier Auboeuf, Franck Mortreux   +14 more
doaj   +1 more source

Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

Nature Communications, 2016
Rela is a transcription factor shown to have seemingly contradictory roles in anabolism and catabolism of cartilage. Here the authors find that Rela prevents chondrocyte apoptosis and that homozygous knockout causes accelerated osteoarthritis in adults ...
Hiroshi Kobayashi, Song Ho Chang, Daisuke Mori, Shozo Itoh, Makoto Hirata, Yoko Hosaka, Yuki Taniguchi, Keita Okada, Yoshifumi Mori, Fumiko Yano, Ung-il Chung, Haruhiko Akiyama, Hiroshi Kawaguchi, Sakae Tanaka, Taku Saito   +14 more
doaj   +1 more source

Aggressive Supratentorial Ependymoma, Fusion-Positive with Extracranial Metastasis: A Case Report [PDF]

Journal of Pathology and Translational Medicine, 2017
Ependymoma is the third most common pediatric primary brain tumor. Ependymomas are categorized according to their locations and genetic abnormalities, and these two parameters are important prognostic factors for patient outcome.
Seong-Ik Kim, Yoojin Lee, Seung Ki Kim, Hyoung Jin Kang, Sung-Hye Park   +4 more
doaj   +1 more source

RelA Is a Component of the Nutritional Stress Activation Pathway of theBacillus subtilisTranscription Factor σ^B [PDF]

Journal of Bacteriology, 2003
ABSTRACTThe general stress regulon ofBacillus subtilisis induced by the activation of the σBtranscription factor. Activation of σBoccurs when one of two phosphatases (RsbU and RsbP), each responding to a unique type of stress, actuates a positive regulator of σBby dephosphorylation. Nutritional stress triggers the RsbP phosphatase.
Shuyu, Zhang, W G, Haldenwang
openaire   +2 more sources

Nucleolar sequestration of RelA (p65) regulates NF-kappaB-driven transcription and apoptosis [PDF]

, 2005
The molecular mechanisms that regulate nuclear NF-kappaB to determine whether the stimulation of this pathway has a pro- or anti-apoptotic effect on cells have yet to be fully defined.
Stark, Lesley A, Dunlop, Malcolm G
core   +1 more source