Results 21 to 30 of about 36,830 (233)

Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA [PDF]

Frontiers in Microbiology, 2019
Amino acid starvation in Escherichia coli activates the enzymatic activity of the stringent factor RelA, leading to accumulation of the alarmone nucleotide (p)ppGpp.
Kathryn Jane Turnbull, Kathryn Jane Turnbull, Kathryn Jane Turnbull, Ievgen Dzhygyr, Ievgen Dzhygyr, Søren Lindemose, Vasili Hauryliuk, Vasili Hauryliuk, Vasili Hauryliuk, Mohammad Roghanian, Mohammad Roghanian, Mohammad Roghanian   +11 more
doaj   +2 more sources

Resistance to African swine fever virus among African domestic pigs appears to be associated with a distinct polymorphic signature in the RelA gene and upregulation of RelA transcription

Virology Journal
African swine fever virus (ASFV) is a highly contagious and fatal hemorrhagic disease of domestic pigs, which poses a major threat to the swine industry worldwide.
Patrick N. Bisimwa, Juliette R. Ongus, Ronald Tonui, Espoir B. Bisimwa, Lucilla Steinaa   +4 more
doaj   +3 more sources

SOX4 and RELA Function as Transcriptional Partners to Regulate the Expression of TNF- Responsive Genes in Fibroblast-Like Synoviocytes

Frontiers in Immunology, 2022
SOX4 belongs to the group C of the SOX transcription factor family. It is a critical mediator of tumor necrosis factor alpha (TNF)-induced transformation of fibroblast-like s-ynoviocytes (FLS) in arthritis.
Kyle Jones, Kyle Jones, Sergio Ramirez-Perez, Sergio Ramirez-Perez, Sean Niu, Sean Niu, Umesh Gangishetti, Umesh Gangishetti, Hicham Drissi, Hicham Drissi, Hicham Drissi, Pallavi Bhattaram, Pallavi Bhattaram   +12 more
doaj   +1 more source

RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer

Scientific Reports, 2022
CD271 (also referred to as nerve growth factor receptor or p75NTR) is expressed on cancer stem cells in hypopharyngeal cancer (HPC) and regulates cell proliferation.
Akira Nakazato, Mai Mochizuki, Rie Shibuya-Takahashi, Haruna Fujimori, Keitaro Fujii, Satoshi Saijoh, Shinkichi Morita, Tomoko Yamazaki, Takayuki Imai, Ikuro Sato, Kennichi Satoh, Kazunori Yamaguchi, Kazuo Sugamura, Jun Yasuda, Kazuto Matsuura, Hideo Shojaku, Yukinori Asada, Keiichi Tamai   +17 more
doaj   +1 more source

C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation

Acta Neuropathologica Communications, 2021
Recurrent C11orf95-RELA fusions (RELA FUS ) are the hallmark of supratentorial ependymomas. The presence of RELA as the fusion partner indicates a close association of aberrant NF-κB activity with tumorigenesis.
Tatsuya Ozawa, Syuzo Kaneko, Frank Szulzewsky, Zhiwei Qiao, Mutsumi Takadera, Yoshitaka Narita, Tadashi Kondo, Eric C. Holland, Ryuji Hamamoto, Koichi Ichimura   +9 more
doaj   +1 more source

Identification of super-enhancer-associated transcription factors regulating glucose metabolism in poorly differentiated thyroid carcinoma

Genetics and Molecular Biology, 2022
This study aimed to uncover transcription factors that regulate super-enhancers involved in glucose metabolism reprogramming in poorly differentiated thyroid carcinoma (PDTC).
Kun Liu, Yongrui Du, Hui Li, Xuexia Lin
doaj   +1 more source

BRCA1 Augments Transcription by the NF-κB Transcription Factor by Binding to the Rel Domain of the p65/RelA Subunit [PDF]

Journal of Biological Chemistry, 2003
BRCA1 is a tumor suppressor gene mutated in cases of hereditary breast and ovarian cancer. BRCA1 protein is involved in apoptosis and growth/tumor suppression. In this study, we present evidence that p65/RelA, one of the two subunits of the transcription factor NF-kappaB, binds to the BRCA1 protein.
Miriam, Benezra, Nathalie, Chevallier, Debra J, Morrison, Timothy K, MacLachlan, Wafik S, El-Deiry, Jonathan D, Licht   +5 more
openaire   +2 more sources

Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice

Scientific Reports, 2022
The fusion protein of uncharacterised zinc finger translocation associated (ZFTA) and effector transcription factor of tumorigenic NF-κB signalling, RELA (ZFTA-RELA), is expressed in more than two-thirds of supratentorial ependymoma (ST-EPN-RELA), but ...
Vicente Herranz-Pérez, Jin Nakatani, Masaki Ishii, Toshiaki Katada, Jose Manuel García-Verdugo, Shinya Ohata   +5 more
doaj   +1 more source

The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects [PDF]

Proceedings of the National Academy of Sciences, 1999
Individual Rel/NF-κB transcription factors, although dispensable for the development and maturation of most hemopoietic cells, are critical regulators of normal immune function. Redundancy among these proteins prompted us to examine the role of Rel and RelA in hemopoiesis by using mice that lack both subunits.
Grossmann, Mathis, Metcalf, Donald, Merryfull, Julie, Beg, Amer, Baltimore, David, Gerondakis, Steve   +5 more
openaire   +3 more sources

The Hippo effector YAP1 biochemically and functionally interacts with the nuclear factor‐kappa B/RELA transcription factor

The FASEB Journal, 2021
The transcriptional co‐activator YAP1 (yes‐associated protein 1) is a critical nuclear effector of the Hippo pathway. The Hippo pathway regulates cell growth, cell motility, cell migration, and carcinogenesis, but poorly defined mechanism. We investigated biochemical and functional interactions between YAP1 and the nuclear factor (NF)‐kappa B/RELA ...
Bekir Cinar, Elijah Said‐Bandy, Marwah Mathkour, Ava Boston, Abdulrahman Dwead, Carlos Moreno   +5 more
openaire   +1 more source