Results 11 to 20 of about 8,557 (134)

Female-biased astrocytic priming shapes early locus coeruleus vulnerability in an Aβ oligomer milieu. [PDF]

Alzheimers Dement
Abstract INTRODUCTION The locus coeruleus (LC) is an early site of Alzheimer's disease (AD) pathology, yet the role of brainstem astrocytes in early, sex‐dependent vulnerability remains unclear. METHODS In 2‐ to 3‐month‐old APP/PS1 mice, we combined in vivo proton magnetic resonance spectroscopy (MRS) of the brainstem with region‐resolved molecular ...
Kushwaha S, Roy Choudhury R, Bhat P, Kumaran SS, Karunakaran S.   +4 more
europepmc   +2 more sources

The ChIP-seq-defined networks of Bcl-3 gene binding support its required role in skeletal muscle atrophy [PDF]

, 2012
NF-kappaB transcriptional activation is required for skeletal muscle disuse atrophy. We are continuing to study how the activation of NF-kB regulates the genes that encode the protein products that cause atrophy. Using ChIP-sequencing we found that Bcl-3,
Jackman, Robert W., Kandarian, Susan C., Wu, Chia-Ling   +2 more
core   +10 more sources

Opposing roles of Nfkb2 gene products p100 and p52 in the regulation of breast cancer stem cells [PDF]

, 2017
Purpose: Nuclear factor-kappa B (NF-κB) signalling has been shown to regulate properties of breast cancer stem cells. However, the specific contribution of the non-canonical NF-κB pathway, components of which are elevated in aggressive breast cancer has ...
Clarkson, Richard, Filomena, Spada, French, Rhiannon, Yeo, Syn Kok   +3 more
core   +2 more sources

Inflammation and NF-κB signaling in prostate cancer : mechanisms and clinical implications [PDF]

, 2018
Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and benign. Due to its high prevalence, it is, however, still the second most common cause of death by cancer in men in the West.
Beyaert, Rudi, Staal, Jens
core   +2 more sources

Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells [PDF]

, 2013
As inhibitor of apoptosis (IAP) proteins can regulate additional signaling pathways beyond apoptosis, we investigated the effect of the second mitochondrial activator of caspases (Smac) mimetic BV6, which antagonizes IAP proteins, on non-apoptotic ...
Eckhardt, Ines, Fulda, Simone, Jennewein, Carla, Rajalingam, Krishnaraj, Tchoghandjian, Aurélie   +4 more
core   +3 more sources

TWEAK/Fn14 and non-canonical NF-kappaB signaling in kidney disease [PDF]

, 2013
The incidence of acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing. However, there is no effective therapy for AKI and current approaches only slow down, but do not prevent progression of CKD. TWEAK is a TNF superfamily cytokine. A
Fernández-Fernández, Beatriz, Mart, Catalina, Ortíz, Alberto, Poveda, Jonay, Sanz, Ana Belén, Selgas, Rafael, Sánchez-Niño, María Dolores, Tabara, Luis C.   +7 more
core   +3 more sources

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2011
Chronic obstructive pulmonary disease (COPD) is a global health problem, and current therapy for COPD is poorly effective and the mainstays of pharmacotherapy are bronchodilators.
Adenuga, Adenuga, Adenuga, Adenuga, Algood, Allison, Andersson, Andre, Anest, Arunachalam, Bannister, Barnes, Beeh, Bertolotti, Bessac, Biswal, Blake, Borchers, Borchers, Borchers, Bowie, Bracke, Caito, Caito, Calabrese, Capelli, Carrero, Carrozza, Celedon, Chen, Chen, Chen, Chen, Chen, Cheung, Cho, Christman, Church, Combadiere, Combadiere, Cosio, Costa, Csiszar, Cullinan, Cullinan, Dahl, De Boer, De Boer, de Boer, De Boer, de Ruijter, Decramer, Dekhuijzen, Dentener, Di Stefano, Dinarello, Donnelly, Duran, Edirisinghe, El Moussaoui, Facchinetti, Feghali-Bostwick, Ferrer, Foronjy, Franciosi, Furukawa, Galasinski, Ganguly, Gargalovic, Georgiou, Ghosh, Gongora, Goven, Gracie, Grumelli, Hardaker, Harding, Harju, Harju, Harrison, He, Hengstermann, Hogg, Hogg, Hongwei Yao, Hoshino, Hoshino, Hoshino, Hung, Hwang, Ichinose, Igishi, Iizuka, Imaoka, Imhof, Irfan Rahman, Ishii, Ito, Ito, Ito, Ito, Jorgensen, Juul, Kamei, Kang, Kang, Kasahara, Kassim, Kawahara, Keatings, Keatings, Kelsen, Kim, Kinnula, Kode, Kucukaycan, Lee, Lee, Lee, Leitges, Liu, Lukacs, Luo, Macnee, MacNee, Mahler, Mak, Malhotra, Mattagajasingh, McComb, Meja, Michaud, Michishita, Milne, Milne, Miotto, Mojtahedi, Moretti, Morrison, Motz, Murooka, Nakamaru, Nan, Netea, Niess, Ning, Nisoli, Nozik-Grayck, Ota, Ota, Pantano, Park, Pesci, Petersen, Petrache, Pinamonti, Porter, Potente, Potente, Rabe, Rahman, Rahman, Rahman, Rahman, Rajendrasozhan, Rajendrasozhan, Rangasamy, Rennard, Repine, Ryter, Rytila, Saetta, Saha, Saha, Sandford, Scherz-Shouval, Scherz-Shouval, Senftleben, Sengupta, Sethi, Sethi, Shapiro, Siedlinski, Simon, Singh, Siva, Sizemore, Soler, Sullivan, Sussan, Suzuki, Thatcher, Thomson, Tomaki, Traves, Trevisani, Tsoumakidou, Tuder, Turato, van der Pouw Kraan, van der Strate, van der Vlies, Van Gool, van Overveld, Vaziri, Vermeulen, Vlahos, Wang, Widdowson, Wright, Wright, Xiao, Yagi, Yamamoto, Yamato, Yang, Yang, Yang, Yang, Yang, Yang, Yao, Yao, Yao, Yao, Yin, Young, Zhang, Zhang, Zheng, Zochbauer-Muller   +230 more
core   +1 more source

RelA/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells [PDF]

, 2008
The balance between antiapoptotic and proapoptotic proteins of the Bcl-2 family is critical in determining the fate of T cells in response to death stimuli.
A., Annibaldi, A., Costanzo, B., Marinari, Levrero, Massimo, Muscolini, Michela, R., Cianfrocca, Tuosto, Loretta, V., Marzano   +7 more
core   +1 more source

Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]

, 2018
The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana, Campese, Antonio Francesco, Felli, MARIA PIA, Ferrandino, Francesca, Grazioli, Paola, Screpanti, Isabella   +5 more
core   +2 more sources

Nuclear factor kappa B as a potential target for pharmacological correction endothelium-associated pathology [PDF]

, 2017
The nuclear factor kappa B (NF-κB) is one of transcription factors. A high interest in studying the biological role of the signal system and its contribution to the development of cardiovascular, oncological and autoimmune diseases is obvious.
Burda, Y. E., Dovgan, A. P., Kostina, D. A., Nadezhdin, S. V., Ragulina, V. A.   +4 more
core   +2 more sources