Results 31 to 40 of about 8,557 (134)

Inhibitor of Apoptosis Proteins as Novel Targets in Inflammatory Processes [PDF]

, 2013
Objective: Inhibitor of apoptosis proteins (IAPs), such as X-linked or cellular IAP 1/2 (XIAP, cIAP1/2), are important regulators of apoptosis. IAP antagonists are currently under clinical investigation as anticancer agents.
Erhardt, Annette, Fürst, Robert, Kracht, Michael, Krombach, Fritz, Mayer, Bettina A., Rehberg, Markus, Reichel, Christoph A., Tiegs, Gisa, Vollmar, Angelika M., Wolf, Alexander, Zahler, Stefan   +10 more
core   +1 more source

NLRP3 Inflammasome‐Mediated Pyroptosis in Osteoporosis: Osteoimmune Mechanisms and Therapeutic Targeting

Journal of Cellular and Molecular Medicine, Volume 29, Issue 16, August 2025.
ABSTRACT Osteoporosis (OP) is a chronic, age‐related skeletal disorder characterised by progressive bone loss and microstructural deterioration, which increases bone fragility and fracture risk. The NOD‐like receptor family pyrin domain‐containing 3 (NLRP3) inflammasome, a multi‐subunit protein complex involved in bone homeostasis, mediates ...
Jiaxuan Fan, Guokai Du, Te Ba, HuiXin Sun   +3 more
wiley   +1 more source

Requirement for the NF-kappa B family member Re1A in the development of secondary lymphoid organs [PDF]

, 2002
The transcription factor nuclear factor (NF)-kappaB has been suggested to be a key mediator of the development of lymph nodes and Peyer's patches. However, targeted deletion of NF-kappaB/ Rel family members has not yet corroborated such a function.
Alcamo, Elizabeth, Baltimore, David, Hacohen, Nir, Hynes, Richard O., Rennert, Paul D., Schulte, Leah C.   +5 more
core  

Mechanisms of NF-κB p65 and strategies for therapeutic manipulation [PDF]

, 2018
The transcription factor NF-κB is a critical regulator of immune and inflammatory responses. In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel, and Rel-B proteins, which form homo- or heterodimers and remain as an ...
Giridharan, Sivagami, Srinivasan, Mythily   +1 more
core   +1 more source

Macrophage Signaling Pathways in Health and Disease: From Bench to Bedside Applications

MedComm, Volume 6, Issue 7, July 2025.
Macrophage functions in phagocytosis, tissue repair, immune regulation, and neuronal network protection. And graphic abract image in the attachment. ABSTRACT Macrophages exhibit remarkable functional plasticity by dynamically polarizing into proinflammatory or antiinflammatory subsets in response to microenvironmental cues. This duality underpins their
Yongquan Chi, Haipeng Jiang, Yiyuan Yin, Xinyu Zhou, Yiyouyou Shao, Yongsheng Li, Jianhua Rao   +6 more
wiley   +1 more source

Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
This review provides a comprehensive overview of common autoimmune diseases, details clinical manifestations and summarizes the pathogenesis, including the breakdown of immune tolerance, initiation of autoimmune responses, and their progressive amplification.
Xiaoshuang Song, Hantian Liang, Fang Nan, Wenjing Chen, Junyao Li, Liu He, Yiping Cun, Zhenhong Li, Wei Zhang, Dunfang Zhang   +9 more
wiley   +1 more source

Differential activation of nuclear factor kappa B subunits in a skin dendritic cell line in response to the strong sensitizer 2,4-dinitrofluorobenzene [PDF]

, 2002
Dendritic cell (DC) maturation is essential for the initiation of T-dependent immune responses. Nuclear factor kappa B (NF-kappaB) transcription factors are ubiquitously expressed signalling molecules, known to regulate the transcription of a large ...
Carvalho, AP, Cruz, MT, Duarte, CB, Figueiredo, A, Gonçalo, Margarida, Lopes, MC   +5 more
core   +1 more source

Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis. [PDF]

, 2008
The nuclear factor-kappa B family of transcription factors is intimately involved in the regulation of the inflammatory responses that play a fundamental role in the damage of articular tissues.
Jimenez, Sergio A., Roman-Blas, Jorge A.
core   +1 more source

An optimised Bcl‐3 inhibitor for melanoma treatment

British Journal of Pharmacology, Volume 182, Issue 11, Page 2426-2446, June 2025.
Abstract Background and Purpose Malignant melanoma is the most lethal form of skin cancer, characterised by a poor survival rate. One of the key factors driving the aggressive growth of melanoma cells is the elevated expression of the proto‐oncogene Bcl‐3. This study aims to optimise, evaluate and characterise a second‐generation Bcl‐3 inhibitor, using
Karunakar Saamarthy, Renée Daams, Wondossen Sime, Cecilia Persson, Eduard Chygorin, Kristofer Ahlqvist, Susan Evans‐Axelsson, Daniel Strand, Ramin Massoumi   +8 more
wiley   +1 more source

NF-κB1 Inhibits TLR-Induced IFN-β Production in Macrophages Through TPL-2-dependent ERK Activation [PDF]

, 2010
available in PMC 2012 February 15.Although NF-κB1 p50/p105 has critical roles in immunity, the mechanism by which NF-κB1 regulates inflammatory responses is unclear.
Agnes Mambole, Amichay, Anne O’Garra, Bruce H. Horwitz, Ezana Demissie, Huei-Ting Yang, Introna, James G. Fox, Kastenbauer, Michal F. Tomczak, Stamatia Papoutsopoulou, Steven C. Ley, Susan E. Erdman, Xixing Zhao, Yanyan Wang   +14 more
core   +1 more source