Results 41 to 50 of about 8,557 (134)

Monoclonal Antibodies to Thyrotropin Receptor With Thyroid‐Stimulating Activity Activate the NF‐κB Pathway to Induce Chemokine Expression

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT The A subunit of thyrotropin receptor (TSHR) is thought to be the crucial gene mediating stimulatory autoantibodies in Graves' diease (GD), but it remains unclear what the molecular basis of this pathological antibody response is. Stimulatory TSHR autoantibodies may induce activation of multiple signalling pathways in GD, modulate chemokine ...
Yang Yang, Chen Hui
wiley   +1 more source

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]

, 2014
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival.
An, Azad, Bartels, Bonello, Centanin, Culver, Cummins, Cummins, Daniel Bandarra, Dekanty, Fandrey, Fu, Glittenberg, H. Arno Muller, Harhaj, Hetru, Jiang, John Biddlestone, Jono, Kenneth, Kounatidis, Lando, Lavista-Llanos, Liu, Lu, Massoumi, Melvin, Moniz, Perkins, Perkins, Ratcliffe, Rius, Rocha, Romero, Ruland, Scholz, Semenza, Sharon Mudie, Silke, Silverman, Silverman, Sonia Rocha, Sonnenfeld, Tornatore, Tsichritzis, van Uden, van Uden, Walmsley, Xue   +48 more
core   +5 more sources

The Malignant Transformation of Viral Hepatitis to Hepatocellular Carcinoma: Mechanisms and Interventions

MedComm, Volume 6, Issue 3, March 2025.
The malignant transformation from chronic viral hepatitis to hepatocellular carcinoma (HCC) involves intricate interactions among viral, host, and environmental factors. Key drivers of this transformation include viral integration, genomic instability, epigenetic modifications, oxidative stress, gut microbiota dysbiosis, chronic inflammation, immune ...
Huimin Yuan, Ruochen Xu, Senlin Li, Mengzhu Zheng, Qingyi Tong, Ming Xiang, Yonghui Zhang   +6 more
wiley   +1 more source

Distinct NF-kB activation pathways engaged by T-cell receptor and co-receptor CD28 on T-cells [PDF]

, 2015
The transcription factor nuclear factor-kB (NF-kB) is critical for the induction of inflammatory responses in T-cells, survival and differentiation. Antigen receptor (TCR) and co-receptor CD28 are the central regulators of NF-kB activation in T-cells ...
Rudd, Christopher E, Thaker, Youg Raj
core   +1 more source

Non-canonical NFκB activation promotes chemokine expression in podocytes [PDF]

, 2016
TNF-like weak inducer of apoptosis (TWEAK) receptor Fn14 is expressed by podocytes and Fn14 deficiency protects from experimental proteinuric kidney disease. However, the downstream effectors of TWEAK/Fn14 in podocytes are poorly characterized.
Gonzalez-Lafuente, Laura, Ortiz, Alberto, Ruiz-Ortega, Marta, Sanchez-Niño, María D., Sanz, Ana Belén, Valiño-Rivas, Lara   +5 more
core   +2 more sources

Role of the Extracellular Matrix in Cancer: Insights into Tumor Progression and Therapy

Advanced Therapeutics, Volume 8, Issue 2, February 2025.
The extracellular matrix (ECM) is pivotal in cancer progression, influencing tumor growth, metastasis, and therapy resistance. This paper explores ECM remodeling, highlighting components like collagens and proteoglycans, their impact on immune evasion, and emerging therapies targeting ECM mechanics and composition.
Nimeet Desai, Deepak Sahel, Bhakti Kubal, Humzah Postwala, Yesha Shah, Vivek P Chavda, Clara Fernandes, Dharmendra K. Khatri, Lalitkumar K. Vora   +8 more
wiley   +1 more source

NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug. [PDF]

, 2012
BACKGROUND: Most DNA-damaging chemotherapeutic agents activate the transcription factor nuclear factor κB (NF-κB). However, NF-κB activation can either protect from or contribute to the growth suppressive effects of the agent.
Ascierto, PA, Atzori, MG, Bonmassar, E, Caporali, S, D'Atri, S, Graziani, G, Levati, L, Muzi, A, Palmieri, G   +8 more
core   +1 more source

Tumor Necrosis Factor‐Alpha Inhibits the Replication of Patient‐Derived Archetype BK Polyomavirus While Activating Rearranged Strains

Journal of Medical Virology, Volume 97, Issue 2, February 2025.
ABSTRACT To date, no drugs are approved for BK polyomavirus (BKPyV) reactivation, a major cause of nephropathy after kidney transplantation. Recently, tumor necrosis factor‐α (TNF‐α) blockade has been proposed as a promising therapy, however, the effect of TNF‐α on the clinically most common archetype (ww) BKPyV remained unclear.
Lise Lauterbach‐Rivière, Lucia Thuringer, Pascal Feld, Lina Kathrin Toews, Jessica Schüssler, Jonas Klinz, Lars Gläser, Stefan Lohse, Anna Sternjakob, Gilles Gasparoni, Kathrin Kattler‐Lackes, Jörn Walter, Marcel A. Lauterbach, Sven Rahmann, Lars Möller, Michael Laue, Martin Janssen, Michael Stöckle, David Schmit, Danilo Fliser, Sigrun Smola   +20 more
wiley   +1 more source

The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma [PDF]

, 2009
Background Gambogic acid (GA) is a major active ingredient of gamboge, a widely used traditional Chinese medicine that has been reported to be a potent cytotoxic agent against some malignant tumors.
Di He, Qin Xu, Ming Yan, Ping Zhang, Xiaojian Zhou, Zhiyuan Zhang, Wenhu Duan, Laiping Zhong, Dongxia Ye, Wantao Chen, A Jemal, MV Blagosklonny, A Panthong, J Asano, QL Guo, QB Han, L Zhao, S Kasibhatla, P Zhang, Q Xu, A Deorukhkar, S Ghosh, M Karin, OS Bindhu, S Ghosh, CY Wang, C Chen, HL Pahl, KC Das, G Sethi, AS Baldwin, AR Setty, JH Lee, H Yang   +33 more
core   +2 more sources

Role of CRISPR‐Cas systems in periodontal disease pathogenesis and potential for periodontal therapy: A review

Molecular Oral Microbiology, Volume 40, Issue 1, Page 1-16, February 2025.
Abstract Clustered regularly interspaced short palindromic repeats (CRISPRs) are DNA sequences capable of editing a host genome sequence. CRISPR and its specific CRISPR‐associated (Cas) protein complexes have been adapted for various applications. These include activating or inhibiting specific genetic sequences or acting as molecular scissors to cut ...
Aditi Chopra, Geeta Bhuvanagiri, Kshitija Natu, Avneesh Chopra   +3 more
wiley   +1 more source