Results 51 to 60 of about 8,557 (134)

Molecular mechanisms of glucocorticoids – anti-inflammatory implications [PDF]

, 2012
Glucocorticoids (GCs) play important roles in many biological processes including inflammatory responses. The study of this process has involved investigations of cross-talk abilities by GC receptor (GR) with cellular signaling pathways that have been ...
Johansson-Haque, Krishan
core   +1 more source

APOBEC3C‐mediated NF‐κB activation enhances clear cell renal cell carcinoma progression

Molecular Oncology, Volume 19, Issue 1, Page 114-132, January 2025.
The authors discovered that expression of the RNA‐binding protein APOBEC3C (A3C) promotes clear cell renal cell carcinoma (ccRCC) growth by amplifying nuclear factor‐kappa B (NF‐κB) activity. A3C‐bound mRNAs of NF‐κB regulators are stabilized, which promotes NF‐κB‐subunit shuttling and transcriptional activity.
Nora Hase, Danny Misiak, Helge Taubert, Stefan Hüttelmaier, Michael Gekle, Marcel Köhn   +5 more
wiley   +1 more source

A screen for transcription factor targets of glycogen synthase kinase-3 highlights an inverse correlation of NFκB and androgen receptor signaling in prostate cancer [PDF]

, 2016
This is an open-access article distributed under the terms of the Creative Commons Attribution License.Expression of Glycogen Synthase Kinase-3 (GSK-3) is elevated in prostate cancer and its inhibition reduces prostate cancer cell proliferation, in part ...
Baltziskueta, Eder, Bengoa-Vergniory, Nora, Campa, Víctor M., Gorroño-Etxebarria, Irantzu, Kypta, Robert M., Waxman, Jonathan, Wesołowski, Radosław   +6 more
core   +1 more source

Identification and study of new NF‐κB‐inducing kinase ligands derived from the imidazolone scaffold

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
A new family of NF‐κB‐inducing kinase (NIK) ligands bearing an imidazolone moiety were synthesized. The best compound showed a dose‐dependent inhibition of p100 to p50 processing in cellular assays, a key step in nuclear factor κB (NF‐κB) activation. Based on computational techniques, a plausible binding mode is proposed.
Francisco Maqueda‐Zelaya, Lara Valiño‐Rivas, Ana Milián, Sara Gutiérrez, José Luis Aceña, Javier Garcia‐Marin, Mª Dolores Sánchez‐Niño, Juan J. Vaquero, Alberto Ortiz   +8 more
wiley   +1 more source

Post-ischemic brain damage: NF-kappaB dimer heterogeneity as a molecular determinant of neuron vulnerability [PDF]

, 2009
Nuclear factor-kappaB (NFkB) has been proposed to serve a dual function as a regulator of neuron survival in pathological conditions associated with neurodegeneration.
BATTISTIN L, LANZILLOTTA A, PIZZI M, SARNICO I, SPANO P   +4 more
core  

NF‐κB Inhibitory Activity of the Di‐Hydroxy Derivative of Piperlongumine (PL‐18)

Journal of Immunology Research, Volume 2025, Issue 1, 2025.
Inflammation is a critical response of the immune system to infection or injury, serving to repair and restore tissue homeostasis. While acute inflammation generally protects against harmful stimuli, prolonged and chronic inflammation have detrimental effects and disrupts tissue homeostasis.
Yael Schlichter Kadosh, Subramani Muthuraman, Ariel Kushmaro, Rajendran Saravana Kumar, Jacob Gopas, Baohui Xu   +5 more
wiley   +1 more source

Pogostemon cablin Acts as a Key Regulator of NF‐κB Signaling and Has a Potent Therapeutic Effect on Intestinal Mucosal Inflammation

Mediators of Inflammation, Volume 2025, Issue 1, 2025.
Persistent intestinal inflammation is a major contributor to various diseases, including digestive disorders, immune dysregulation, and cancer. The NF‐κB signaling pathway is pivotal in the inflammatory response of intestinal cells, regulating the secretion of inflammatory factors, mediating signal transduction, and activating receptors. In colitis, NF‐
Yuqing Deng, Xin Liang, Long Zhao, Xin Zhou, Jianqin Liu, Zhi Li, Shanshan Chen, Guohui Xiao, Palash Mandal   +8 more
wiley   +1 more source

Fullerene‐Based Immunoregulatory Nanomaterials for Immunotherapy of Tumor and Immune‐Related Inflammatory Diseases

Advanced Functional Materials, Volume 34, Issue 49, December 2, 2024.
Fullerene‐based immunomodulatory nanomaterials have a dual immunomodulatory mechanism. They activate the immune system after immunosuppression, giving them powerful roles in tumor immunotherapy and tumor‐enhancing immunotherapy. In addition, fullerene nanomaterials inhibit over‐activated immunity, developing different strategies to suppress related ...
Mingming Zhen, Yuan Xu, Chunru Wang, Chunli Bai   +3 more
wiley   +1 more source

The caspase-3-p120-RasGAP module generates a NF-κB repressor in response to cellular stress. [PDF]

, 2015
The nuclear factor κB (NF-κB) transcription factor is a master regulator of inflammation. Short-term NF-κB activation is generally beneficial. However, sustained NF-κB might be detrimental, directly causing apoptosis of cells or leading to a persistent ...
Annibaldi, Annibaldi, Baker, Bakry, Baldwin, Barnes, Ben-Neriah, Ben-Neriah, Bonizzi, Bulat, Calabrese, Chaudhary, Chung, Cook, Courtois, Cross, Darding, Englmeier, Gardam, Gerondakis, Hu, Hutten, Jaeschke, Jordan, Kane, Khalil, Khalil, Kopp, Kreuz, Kudo, Kumar, Lamkanfi, Lamkanfi, Lange, Lawrence, Lawrence, Laychock, Li, Marchetti, May, Nemergut, Newton, Oeckinghaus, Oeckinghaus, Ozes, Pasparakis, Pasparakis, Perkins, Romashkova, Salmena, Schmidt, Sen, Sen, Stoven, Stratis, Su, Trahey, Vallabhapurapu, Verma, Viatour, Wambier, Weissgerber, Wen, Widmann, Wong, Yamamoto, Yang, Yang, Yang, Yang, Yang, Yang, Yoon   +72 more
core   +1 more source

NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1 [PDF]

, 2013
The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3
Bernhardt, Katharina, Ersing, Ina, Gewurz, Benjamin E.   +2 more
core   +4 more sources