Results 61 to 70 of about 67,683 (260)

Guanfacine treatment improves ADHD phenotypes of impulsivity and hyperactivity in a neurofibromatosis type 1 mouse model

Journal of Neurodevelopmental Disorders, 2020
Background Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with a mutation in one copy of the neurofibromin gene (NF1 +/− ). Even though approximately 40–60% of children with NF1 meet the criteria for attention deficit hyperactivity ...
J. L. Lukkes, H. P. Drozd, S. D. Fitz, A. I. Molosh, D. W. Clapp, A. Shekhar   +5 more
doaj   +1 more source

MEK inhibition exerts temporal and myeloid cell-specific effects in the pathogenesis of neurofibromatosis type 1 arteriopathy

Scientific Reports, 2021
Mutations in the NF1 tumor suppressor gene are linked to arteriopathy. Nf1 heterozygosity (Nf1+/–) results in robust neointima formation, similar to humans, and myeloid-restricted Nf1+/– recapitulates this phenotype via MEK-ERK activation. Here we define
Rebekah Tritz, Farlyn Z. Hudson, Valerie Harris, Pushpankur Ghoshal, Bhupesh Singla, Huiping Lin, Gabor Csanyi, Brian K. Stansfield   +7 more
doaj   +1 more source

Emergence of scalar matter from spinfoam model [PDF]

, 2009
A spinfoam model of 3D gravity non-minimally coupled with a scalar field is studied. By discretization of the scalar field, the model is worked out precisely in a purely combinational way.
Ma, Yongge, Xu, Peng
core   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Unilateral Yasunari nodule-like appearance in a patient without neurofibromatosis type 1

European Journal of Case Reports in Internal Medicine
Introduction: Yasunari nodules are choroidal lesions characterized by bright, poorly demarcated multiple lesions detected through near-infrared reflectance imaging and are considered diagnostic for neurofibromatosis type 1 (NF1).
Hamit Ali, Nargis Ahmadova, Özlem Ural Fatihoglu, Mehmet Kocabey, Ahmet Okay Caglayan, Ali Osman Saatci   +5 more
doaj   +1 more source

Semi-naive dimensional renormalization [PDF]

, 1999
We propose a treatment of $\gamma^5$ in dimensional regularization which is based on an algebraically consistent extension of the Breitenlohner-Maison-'t Hooft-Veltman (BMHV) scheme; we define the corresponding minimal renormalization scheme and show its
't Hooft, 't Hooft, Adelhafiz, Adler, Akyeampong, Ashmore, Baikov, Bardeen, Bardeen, Bollini, Bonneau, Bonneau, Bos, Braaten, Breitenlohner, Buras, Caswell, Chanowitz, Cicuta, Collins, Collins, Ferrari, Gottlieb, Jones, Korner, Korner, Kreimer, Larin, M. Pernici, Machacek, Martin, Nicolai, Pernici, Schubert, Trueman, Veltman, Zinn-Justin   +36 more
core   +2 more sources

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Outlook for Neurofi bromatosis Type I Research in the Republic of Bashkortostan

Креативная хирургия и онкология, 2020
Neurofi bromatosis type I (NF1) is a common hereditary tumour syndrome with autosomal dominant type of inheritance. Average worldwide incidence rate of NF1 is 1:3000, equal in men and women.
R. N. Mustafin, E. K. Khusnutdinova
doaj   +1 more source

Development of algorithms to identify individuals with Neurofibromatosis type 1 within administrative data and electronic medical records in Ontario, Canada

Orphanet Journal of Rare Diseases, 2022
Background There is limited population-based data on Neurofibromatosis type 1 (NF1) in North America. We aimed to develop and validate algorithms using administrative health data and electronic medical records (EMRs) to identify individuals with NF1 in ...
Carolina Barnett, Elisa Candido, Branson Chen, Priscila Pequeno, Patricia C. Parkin, Karen Tu   +5 more
doaj   +1 more source

Gold(III)-pyrrolidinedithiocarbamato Derivatives as Antineoplastic Agents [PDF]

, 2015
Transition metals offer many possibilities in developing potent chemotherapeutic agents. They are endowed with a variety of oxidation states, allowing for the selection of their coordination numbers and geometries via the choice of proper ligands ...
Brustolin, Leonardo, Chiara, Federica, Ciscato, Francesco, Fregona, Dolores, Gambalunga, Alberto, Nardon, Chiara, Rasola, Andrea, Trevisan, Andrea   +7 more
core   +2 more sources