Results 11 to 20 of about 28,866 (196)
Cell Death and Disease, 2021 Neurofibromin 2 (NF2, also known as merlin) is a tumor suppressor protein encoded by the neurofibromatosis type 2 gene NF2. NF2 is also an actin-binding protein that functions in an intrinsic signaling network critical for actin dynamics.
Ji-Eun Kim +5 more
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Cell Reports, 2021 Summary: Germline alterations of the NF2 gene cause neurofibromatosis type 2, a syndrome manifested with benign tumors, and Nf2 deletion in mice also results in slow tumorigenesis.
Yu Wang +12 more
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Scientific Reports, 2023 NF2-related schwannomatosis (NF2) is an autosomal dominant genetic disorder caused by variants in the NF2 gene. Approximately 50% of NF2 patients inherit pathogenic variants, and the remainder acquire de novo variants. NF2 is characterized by development
Naoki Oishi +12 more
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iScience, 2022 Summary: Neurofibromatosis type 2 is an autosomal dominant multiple neoplasia syndrome and is usually caused by mutations in the neurofibromin 2 (NF2) gene, which encodes a tumor suppressor and initiates the Hippo pathway. However, the mechanism by which
Zexiao Jia +18 more
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Quinacrine Has Preferential Anticancer Effects on Mesothelioma Cells With Inactivating NF2 Mutations
Frontiers in Pharmacology, 2021 Mesothelioma is a rare cancer with disproportionately higher death rates for shipping and mining populations. These patients have few treatment options, which can be partially attributed to limited chemotherapy responses for tumors.
Derek B. Oien +5 more
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Neurofibromatosis type 2 tumor suppressor protein, NF2, induces proteasome-mediated degradation of JC virus T-antigen in human glioblastoma. [PDF]
PLoS ONE, 2013 Neurofibromatosis type 2 protein (NF2) has been shown to act as tumor suppressor primarily through its functions as a cytoskeletal scaffold. However, NF2 can also be found in the nucleus, where its role is less clear. Previously, our group has identified
Sarah Beltrami +5 more
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NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations. [PDF]
, 2013 Inactivating germline mutations in the tumor suppressor gene NF2 cause the hereditary syndrome neurofibromatosis 2, which is characterized by the development of neoplasms of the nervous system, most notably bilateral vestibular schwannoma.
Angelo, Laura S +2 more
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Benign retroperitoneal schwannoma presenting as colitis: A case report [PDF]
, 2007 We report a case of a patient presenting with clinical , radiological and endoscopic features of colitis due to a compressive left para-aortic mass.
Claes, Kathleen +7 more
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Conformational flexibility determines the Nf2/merlin tumor suppressor functions
Matrix Biology Plus, 2021 The Neurofibromatosis type 2 gene encodes the Nf2/merlin tumor suppressor protein that is responsible for the regulation of cell proliferation. Once activated, Nf2/merlin modulates adhesive signaling pathways and thereby inhibits cell growth.
Marina C. Primi +3 more
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Branes, Geometry and N=1 Duality with Product Gauge Groups of SO and Sp [PDF]
, 1997 We study N=1 dualities in four dimensional supersymmetric gauge theories as the worldvolume theory of D4 branes with one compact direction in type IIA string theory. We generalize the previous work for SO(N_{c1}) x Sp(N_{c2}) with the superpotential W=Tr
Ahn, Changhyun, Oh, Kyungho, Tatar, Radu
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