Results 41 to 50 of about 28,866 (196)

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. [PDF]

, 2015
The Hippo pathway plays a central role in tissue homoeostasis, and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include a kinase cascade of MST1/2 and LATS1/2 and the transcription co-activators YAP/TAZ.
Flores, Fabian, Guan, Kun-Liang, Halder, Georg, Hansen, Carsten G, Hong, Audrey W, Lu, Shicong, Lu, Wenqi, Meng, Zhipeng, Mo, Jung-Soon, Moroishi, Toshiro, Mottier-Pavie, Violaine, Park, Hyun Woo, Plouffe, Steven W, Yu, Fa-Xing   +13 more
core   +2 more sources

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

On the hadronic contribution to sterile neutrino production [PDF]

, 2006
Sterile neutrinos with masses in the keV range are considered to be a viable candidate for warm dark matter. The rate of their production through active-sterile neutrino transitions peaks, however, at temperatures of the order of the QCD scale, which ...
A. Boyarsky, A. Boyarsky, A. Boyarsky, A.I. Bochkarev, A.L. Fetter, E.W. Kolb, G. Aarts, J. Bernstein, J.W. Negele, K. Abazajian, M. Laine, M. Le Bellac, M. Shaposhnikov, P. Arnold, P. Arnold, P. Arnold, P. Aurenche, S. Doniach, S. Riemer-Sørensen, T. Asaka, T. Asaka, U. Seljak, V.N. Tsytovich   +22 more
core   +4 more sources

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

Dependence Balance Based Outer Bounds for Gaussian Networks with Cooperation and Feedback

, 2008
We obtain new outer bounds on the capacity regions of the two-user multiple access channel with generalized feedback (MAC-GF) and the two-user interference channel with generalized feedback (IC-GF).
Tandon, Ravi, Ulukus, Sennur
core   +4 more sources

KMT2C Loss Promotes NF2‐Wildtype Meningioma Progression and Ferroptosis Sensitivity via Epigenetic Repression of Hippo Signaling

Advanced Science, EarlyView.
In NF2–wild‐type meningiomas, loss of the epigenetic regulator KMT2C suppresses NF2 transcription and inactivates Hippo signaling, driving tumor progression and increasing ferroptosis sensitivity. Restoration of histone acetylation reverses these effects and inhibits tumor growth, identifying KMT2C as a key regulator linking epigenetic control, NF2 ...
Liuchao Zhang, Yangfan Ye, Wei Gu, Xinyue Wang, Nuo Chen, Qixin He, Lei Xu, Pengzhan Zhao, Guoqiang Fu, Guangyao Yuan, Wenqian Shi, Honglu Chao, Yiming Tu, Jing Ji   +13 more
wiley   +1 more source

Isolation and Characterization of Schwann Cells from Neurofibromatosis Type 2 Patients

Neurobiology of Disease, 1998
Neurofibromatosis type 2 (NF2) is an autosomal dominant disease of the nervous system characterized by multiple schwannomas. The NF2 gene product, termed schwannomin or merlin, was hypothesized to function as a cytoskeleton–membrane linking protein due ...
C. Rosenbaum, L. Kluwe, V.F. Mautner, R.E. Friedrich, H.W. Müller, C.O. Hanemann   +5 more
doaj   +1 more source

NF2-Related Schwannomatosis (NF2): Molecular Insights and Therapeutic Avenues

International Journal of Molecular Sciences
NF2-related schwannomatosis (NF2) is a genetic syndrome characterized by the growth of benign tumors in the nervous system, particularly bilateral vestibular schwannomas, meningiomas, and ependymomas. This review consolidates the current knowledge on NF2 syndrome, emphasizing the molecular pathology associated with the mutations in the gene of the same
Bae-Hoon Kim, Yeon-Ho Chung, Tae-Gyun Woo, So-mi Kang, Soyoung Park, Minju Kim, Bum-Joon Park   +6 more
openaire   +2 more sources

Neurodevelopmental and Psychiatric Studies in Children and Adolescents With Neurofibromatosis Type I: A Comprehensive Scoping Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT A comprehensive synthesis of the broad range of neurodevelopmental and psychiatric manifestations in NF1 is needed to identify knowledge gaps and future directions for NF1 research. In the following scoping review, we identify and summarize the scope of research that examines neurodevelopmental and psychiatric manifestations, both as ...
Meera Chopra, Tin‐Suet Joan Lee, Jacob Vorstman, Patricia Parkin, Louise Gallagher, Aneta Krakowski   +5 more
wiley   +1 more source

Target enrichment using parallel nanoliter quantitative PCR amplification [PDF]

, 2014
Background: Next generation targeted resequencing is replacing Sanger sequencing at high pace in routine genetic diagnosis. The need for well validated, high quality enrichment platforms to complement the bench-top next generation sequencing devices is ...
De Wilde, Bram, Derveaux, Stefaan, Dong, Wes, Dunne, Jude, Hellemans, Jan, Husain, Syed, Lefever, Steve, Vandesompele, Jo   +7 more
core   +2 more sources