Results 131 to 140 of about 17,594 (242)

Biochemical and Immunohistochemical Associations of TDP‐43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease

Annals of Neurology, Volume 100, Issue 1, Page 193-205, July 2026.
Objective Immunohistochemically (IHC) measured transactive response DNA‐binding protein 43 (TDP‐43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation of cryptic exons occurs in AD in response to TDP‐43 pathology.
Hossam Youssef, Rodolfo G. Gatto, Nikhil B. Ghayal, Virginia Estades Ayuso, Karen R. Jansen‐West, Judith A. Dunmore, Yuping Song, Mei Yue, Casey N. Cook, Michael DeTure, Bailey D. Rawlinson, Monica Castanedes‐Casey, Clifford R. Jack Jr, Ronald C. Petersen, Dennis W. Dickson, Leonard Petrucelli, Jennifer L. Whitwell, Mercedes Prudencio, Keith A. Josephs   +18 more
wiley   +1 more source

NFT Marketplace

International Journal of Scientific Research in Engineering and Management
Abstract— The rapid growth of blockchain technology has transformed the creation and exchange of digital assets through Non-Fungible Tokens (NFTs). Despite this progress, existing NFT marketplaces continue to face significant challenges, including high transaction costs, centralized metadata storage, lack of transparency in royalty distribution ...
SOUVIK DAS, DR. VAISHALI SHENDE, JITANSHU TIWARI, SUYASH SINGH, VIPUL SHARMA   +4 more
openaire   +1 more source

Advances in the Core Role and Mechanisms of Mitochondrial Dysfunction in Alzheimer's Disease

Brain and Behavior, Volume 16, Issue 7, July 2026.
In Alzheimer's disease, Aβ and Tau trigger mitochondrial dysfunction, driving a pathological cascade that results in cognitive decline. Gut microbiota dysbiosis exacerbates this via the gut–brain axis, making mitochondria a key therapeutic target. ABSTRACT Introduction Alzheimer's disease (AD) is a complex neurodegenerative disorder whose pathogenesis ...
Tianyi Gu, Hangyan Guo, Zixin Guo, Shengyu Hua   +3 more
wiley   +1 more source

Clinical, Radiological, and Immunohistological Distinctions Between Limbic‐Predominant and Typical Alzheimer's Disease: A Systematic Review

Brain and Behavior, Volume 16, Issue 7, July 2026.
Abstract Background Alzheimer's disease (AD) is the most common cause of dementia worldwide and one of the leading causes of morbidity and mortality among elderly people. It is characterized by generalized brain atrophy, especially affecting the hippocampus and medial temporal lobe.
Guilherme Linha Secco, Kashif Qureshi, Murtaja Satea Shafeea, Pedro Henrique Karpinski, Kim Wouters, Mateus Cordeiro Merlim da Silva, Sravan Reddy Ganta, Enzo von Quednow, Edgar Daniel Guzmán‐Ríos, Khalil St Brice, Mahi Dsouza, Ailton Fernandes Junior, Noor Najah Noori, Bipin Chaurasia, Kivanc Yangi   +14 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Do you believe in the metaverse NFTs? Understanding the value proposition of NFTs in the metaverse

This study investigates consumer intention to purchase NFTs in the metaverse using the underpinnings of the theory of consumption values (TCV). This study uses a sequential mixed-methods approach (qualitative + quantitative) to explore and examine the ...
Behl, Abhishek, Wamba, Samuel Fosso, Shankar, Amit, Kumar, Aman   +3 more
core   +1 more source

Association of SPHK1 polymorphisms with Alzheimer's disease susceptibility: Functional impact of the rs2247856 SNP on transcriptional efficiency

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION Sphingosine kinase 1 (SPHK1) has been implicated in the regulation of pro‐resolving lipid mediators relevant to neuroinflammation in Alzheimer's disease (AD). However, no studies have evaluated the genetic association between SPHK1 polymorphisms and AD susceptibility.
Dong‐Ju Kim, Yong‐Chan Kim, Byung‐Hoon Jeong   +2 more
wiley   +1 more source

Distinct regional patterns of synaptic vulnerability across hippocampal and parahippocampal subregions in Alzheimer's disease

Brain Pathology, Volume 36, Issue 4, July 2026.
Synaptic loss in Alzheimer's disease predominantly affects the entorhinal cortex and parahippocampal gyrus. Amyloid‐β and p‐tau pathology show global associations with synaptic density but are limited in specific subregions. Instead, axonal damage associates with synaptic loss locally and in interconnected subregions.
Maud M. A. Bouwman, Irene Frigerio, Yvon Galis‐de Graaf, Wilma D. J. van de Berg, Laura E. Jonkman   +4 more
wiley   +1 more source

Coalition Formation for Sustainable Blockchain Governance: Insights From the Hedera Case

Information Systems Journal, Volume 36, Issue 4, Page 485-499, July 2026.
ABSTRACT Sustainable governance is essential for blockchain networks to achieve widespread adoption and deliver long‐term business value. Prior blockchain initiatives indicate that inadequate governance structures often lead to limited adoption or eventual project failure, underscoring the importance of decentralised governance for building resilient ...
Christophe Viguerie, Horst Treiblmaier
wiley   +1 more source

Non-Fungible Token (NFTs) im Aufsichtsrecht

Die Dissertation analysiert Non-Fungible Tokens (NFTs) im europäischen und deutschen Aufsichtsrecht. Ausgangspunkt ist eine Arbeitsdefinition von „Token“ sowie die Entwicklung eines Begriffs des NFTs im aufsichtsrechtlichen Kontext mit Unterteilung in ...
Goldschmidt, Oleg
core   +1 more source