Results 51 to 60 of about 29,096 (243)

Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease [PDF]

, 2014
The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD).
*EQUAL CONTRIBUTION, Adele Romano*, Angelo Michele Lavecchia, Caterina Grillo, F.m. Laferla, Fabio Altieri, Gaurav Bedse*, Gianluigi Vendemiale, Lorenzo Federico Pace, M.r. Elphick, Silvana Gaetani, Silvia Cianci, Tommaso Cassano   +12 more
core   +1 more source

NFT Mart

International Journal For Multidisciplinary Research, 2023
Non Fungible Tokens which are commonly known as NFT’s are digital items such as audios, Videos, Photographs etc. NFT’s are unique cryptographic tokens that exist on a blockchain and cannot be replicated. All Non Fungible Tokens have unique identification codes and metadata that differentiate each token from each other.
Jay Joshi -, Shivani More -, Vineet Kunder -, Karan Patel -, Sareen Deore -   +4 more
openaire   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model [PDF]

, 2011
Neurofibrillary tangles are a feature of Alzheimer disease and other tauopathies, and while they are generally believed to be markers of neuronal pathology, there is little evidence evaluating whether tangles directly impact neuronal function.
Adamowicz, David H, Carlson, George A, Fox, Leora M, Hyman, Bradley T, Pitstick, Rose, Spires-Jones, Tara L, William, Christopher M   +6 more
core   +1 more source

Hub genes and diagnostic model associated with mitochondrial function in Alzheimer's disease

Animal Models and Experimental Medicine, EarlyView.
Alzheimer's disease (AD) is the most common neurodegenerative disorder, and mitochondrial dysfunction has been confirmed in AD patients and mouse models. However, the pathogenic genes associated with AD and early diagnostic methods based on mitochondrial function remain to be explored.
Xuchao Zhu, Ling Zhang, Chuan Qin
wiley   +1 more source

Between process and object: NFTs and the artification of digital assets

Acta Universitatis Wratislaviensis. Prace Kulturoznawcze
By bringing digital artworks to one’s everyday shopping list, NFTs have revolutionized a large group’s understanding of art. In this article, I challenge the stance presented by authors such as Taylor and Sloane that NFTs shift the consumption of objects
Bogna J. Gladden-Obidzińska
doaj   +1 more source

Recent Insights Into Alzheimer's Disease: Advances in Pathophysiology and Therapeutic Strategies

Brain Health, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a complex neurodegenerative disorder driven by interplay among amyloid‐β (Aβ) plaques, tau neurofibrillary tangles, inflammation and comorbid pathologies. Recent advances in biomarkers and therapeutic approvals have reshaped our understanding of its pathophysiology and treatment landscape.
Jiong Shi, Jeffery Cummings, Jacques Touchon, Bruno Vellas   +3 more
wiley   +1 more source

EXPLORANDO EL LABERINTO FISCAL DE LOS ACTIVOS DIGITALES: EL CASO DE LOS NFTS

Crónica Tributaria
Los tokens no fungibles, o NFTs, son activos digitales únicos e indivisibles que han ganado popularidad en el mercado del arte, los videojuegos y la música.
Estefanía Harana Suano
doaj   +1 more source

Consumer Responses to Physical, Digital and Integrative Sustainability Strategies in the Apparel Industry: A Systematic Review

Business Strategy and the Environment, EarlyView.
ABSTRACT The apparel industry is one of the world's most profitable sectors but also among the most environmentally damaging. Growing sustainability pressures have led companies to adopt diverse strategies to reduce their impact, yet no single study has systematically analysed these approaches or their consumer implications.
Maria Leonor Ferreira, João J. Ferreira   +1 more
wiley   +1 more source

Fundamental concepts of virtual assets and the mechanism of their functioning

Економіка, управління та адміністрування
The classification of digital phenomena, particularly virtual assets, requires a systemic, terminological, and functional-legal approach that enables the structural organization of the diversity of emerging assets in the digital environment. This article
S.M. Zashchypas
doaj   +1 more source