Results 91 to 100 of about 382,279 (282)

Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer. [PDF]

, 2019
Whole exome sequencing (WES), targeted gene panel sequencing and single nucleotide polymorphism (SNP) arrays are increasingly used for the identification of actionable alterations that are critical to cancer care.
Carpten, John D, Kaur, Pushpinder, Lang, Julie E, Porras, Tania B, Ring, Alexander   +4 more
core   +3 more sources

PAGBUO NG GLOSARYO NG MGA SALITANG GINAGAMIT NG MGA BALAYEÑONG MANGINGISDA

, 2021
Ang layunin ng pananaliksik na ito ay ang makabuo ng isang glosaryong babasahin ng mga salitang ginagamit ng mga Balayeñong mangingisda, matukoy kung saang bahagi ng panalita nabibilang ang mga salitang nakalap, mabigyan ng natatanging kahulugan at maipabalideyt ang glosaryong nabuo.
CABRAL, ANACLETO D., MANDAC, ELLA JANE D., MARQUEZ, KENNETH V., MENDOZA, JESS V.   +3 more
openaire   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Decentralization of Next-Generation RNA Sequencing-Based MammaPrint® and BluePrint® Kit at University Hospitals Leuven and Curie Institute Paris

Translational Oncology, 2019
A previously developed and centrally validated MammaPrint® (MP) and BluePrint® (BP) targeted RNA next-generation sequencing (NGS) kit was implemented and validated in two large academic European hospitals.
Laurence Slembrouck, Lauren Darrigues, Cecile Laurent, Lorenza Mittempergher, Leonie JMJ Delahaye, Isabelle Vanden Bempt, Sara Vander Borght, Liesbet Vliegen, Petra Sintubin, Virginie Raynal, Mylene Bohec, Cécile Reyes, Audrey Rapinat, Céline Helsmoortel, Lynn Jongen, Griet Hoste, Patrick Neven, Hans Wildiers, Ann Smeets, Ines Nevelsteen, Kevin Punie, Els Van Nieuwenhuysen, Sileny Han, Anne Vincent Salomon, Enora Laas Faron, Timothé Cynober, David Gentien, Sylvain Baulande, Mireille HJ Snel, Anke T Witteveen, Sari Neijenhuis, Annuska M Glas, Fabien Reyal, Giuseppe Floris   +33 more
doaj   +1 more source

NGS-Integrator: An efficient tool for combining multiple NGS data tracks using minimum Bayes’ factors

BMC Genomics, 2020
Background Next-generation sequencing (NGS) is widely used for genome-wide identification and quantification of DNA elements involved in the regulation of gene transcription.
Bronte Wen, Hyun Jun Jung, Lihe Chen, Fahad Saeed, Mark A. Knepper   +4 more
doaj   +1 more source

Presumed TP53 mosaicism: variants detected using a NGS hereditary cancer multigene panel [PDF]

, 2019
Aims/Context: NGS multigene panels are routinely used to identify germline pathogenic variants in cancer susceptibility genes. In addition, NGS allows the identification of low-level mosaicism events that may not be detectable by conventional Sanger ...
Gonçalves, João, Rodrigues, Márcia, Rodrigues, Pedro, Silva, Catarina, Theisen, Patrícia, Vieira, Luís   +5 more
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Error correction and diversity analysis of population mixtures determined by NGS [PDF]

, 2014
The impetus for this work was the need to analyse nucleotide diversity in a viral mix taken from honeybees. The paper has two findings. First, a method for correction of next generation sequencing error in the distribution of nucleotides at a site is ...
Burroughs, Nigel J., Evans, David J., Ryabov, Eugene V., Wood, Graham R.   +3 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Converting NAD83 GPS heights into NAVD88 elevations with LVGEOID, a hybrid geoid height model for the Long Valley volcanic region, California [PDF]

, 2008
A GPS survey of leveling benchmarks done in Long Valley Caldera in 1999 showed that the application of the National Geodetic Survey (NGS) geoid model GEOID99 to tie GPS heights to historical leveling measurements would significantly underestimate the
BATTAGLIA, MAURIZIO, D. DZURISIN, D. P. HILL, J. LANGBEIN, J. SVARC   +4 more
core