Results 101 to 110 of about 382,279 (282)

Gemini multi-conjugate adaptive optics system review II: Commissioning, operation and overall performance

, 2014
The Gemini Multi-conjugate Adaptive Optics System - GeMS, a facility instrument mounted on the Gemini South telescope, delivers a uniform, near diffraction limited images at near infrared wavelengths (0.95 microns- 2.5 microns) over a field of view of ...
Arriagada, Gustavo, Bec, Matthieu, Boccas, Maxime, Carrasco, Eleazar Rodrigo, Colazo, Felipe, d'Orgeville, Céline, Diggs, Sarah J., Ebbers, Angelic W., Edwards, Michelle L., Fesquet, Vincent, Galvez, Ramon L., Garrel, Vincent, Gausachs, Gaston, Lopez, Ariel, Lührs, Javier, Marchant, Claudio, Marin, Eduardo, McGregor, Peter, Montes, Vanessa, Moreno, Cristian, Neichel, Benoit, Pessev, Peter, Rambold, William N., Rigaut, François, Serio, Andrew, Trancho, Gelys, Trujillo, Chadwick, Urrutia, Cristian, van Dam, Marcos A., Vidal, Fabrice, Vucina, Tomislav B., Winge, Claudia, Young, Peter J.   +32 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Comparison of Different HIV-1 Resistance Interpretation Tools for Next-Generation Sequencing in Italy

Viruses
Background: Next-generation sequencing (NGS) is gradually replacing Sanger sequencing for HIV genotypic drug resistance testing (GRT). This work evaluated the concordance among different NGS-GRT interpretation tools in a real-life setting.
Daniele Armenia, Luca Carioti, Valeria Micheli, Isabella Bon, Tiziano Allice, Celestino Bonura, Bianca Bruzzone, Fiorenza Bracchitta, Francesco Cerutti, Giovanni Maurizio Giammanco, Federica Stefanelli, Maria Addolorata Bonifacio, Ada Bertoli, Marialinda Vatteroni, Gabriele Ibba, Federica Novazzi, Maria Rosaria Lipsi, Nunzia Cuomo, Ilaria Vicenti, Francesca Ceccherini-Silberstein, Barbara Rossetti, Antonia Bezenchek, Francesco Saladini, Maurizio Zazzi, Maria Mercedes Santoro   +24 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Application of Next-Generation Sequencing (NGS) Techniques for Selected Companion Animals

Animals
Next-Generation Sequencing (NGS) techniques have revolutionized veterinary medicine for cats and dogs, offering insights across various domains.
Kinga Domrazek, Piotr Jurka
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Navigating the Rapids : The Development of NGS-based Clinical Trial Assays and Companion Diagnostics

Frontiers in Oncology, 2014
Over the past decade, next generation sequencing (NGS) technology has experienced meteoric growth in the aspects of platform, technology and supporting bioinformatics development allowing its widespread and rapid uptake in research settings.
Saumya ePant, Russell eWeiner, Matthew John Marton   +2 more
doaj   +1 more source

Kabisaan ng Dulog Eksperyensyal sa Pagtuturo ng Gramatika sa mga Mag-Aaral ng Filipino 11 ng Pamantasan ng Bohol

UB Advancing Filipino Research Journal
Nilalayon ng pag-aaral na ito ang masukat ang kabisaan ng dulog eksperyensyal sa pagtuturo ng gramatika sa mga mag-aaral ng Filipino 11 ng Senior High School ng Pamantasan ng Bohol, Siyudad ng Tagbilaran, Bohol, Unang Semestre, Taong Panuruan 2019-2020: Mungkahing Kaparaanang Pampagpabuti.
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A One-year Hospital System Review of Plasma Next-Generation Sequencing in a Mixed Population

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: To describe whether detecting plasma microbial cell-free DNA by next-generation sequencing (NGS) provided additional information compared to routine cultures or led to change in antimicrobial management.
Ty Drake, Jessica Babic, Audrey Wanger, Violeta Chavez   +3 more
doaj   +1 more source