Results 121 to 130 of about 382,279 (282)

NGS Panels applied to Hereditary Cancer Syndromes [PDF]

, 2019
Cancer is among the leading causes of morbidity and mortality worldwide (Okur et al, 2017). Germline pathogenic variants for monogenic, highly penetrant cancer susceptibility genes are observed in 5%–10% of all cancers (Lu et al, 2014).
Gonçalves, João, Rodrigues, Pedro, Silva, Catarina, Theisen, Patrícia, Vieira, Luís   +4 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A comprehensive assessment of Next‐Generation Sequencing variants validation using a secondary technology

Molecular Genetics & Genomic Medicine, 2019
Background Recently, increasing innovations improved the accuracy of next generation sequencing (NGS) data. However, the validation of all NGS variants increased the cost and turn‐around time of clinical diagnosis, and therefore limited the further ...
Jianchao Zheng, Hongyun Zhang, Santasree Banerjee, Yun Li, Junyu Zhou, Qian Yang, Xuemei Tan, Peng Han, Qinmei Fu, Xiaoli Cui, Yuying Yuan, Meiyan Zhang, Ruiqin Shen, Haifeng Song, Xiuqing Zhang, Lijian Zhao, Zhiyu Peng, Wei Wang, Ye Yin   +18 more
doaj   +1 more source

Lawak ng Pagkatuto ng Mag-aaral Kaugnay saPaggamit ng Differentiated Instruksyon

, 2020
Ang pag-aaral na ito ay pagsusuri sa lawak ng pagkatuto ng mga mag-aaral kaugnay sa paggamit ng Differentiated instruksyon. Ang mga respondent ng pananaliksik na ito ay ang piling mga mag-aaral at mga guro na kasalukuyang nagtuturong asignaturang Filipino na gumamit ng differentiated instruksyon sa kanilang pagtuturo.
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Plasma-based next generation sequencing in advanced non-small cell lung cancer (NSCLC): significance in diagnosis and treatment in Asian patients

BMC Cancer
NGS is recommended by NCCN and ESMO in evaluation of advanced NSCLC prior to treatment as being eligible for target therapy has important treatment implications. However, up to 20% of tissue biopsies are insufficient to run molecular testing for all nine
Cherng-Horng Wu, Xia Wu, Xiao Hu, Alice Kennedy, Lori Pai   +4 more
doaj   +1 more source

ANTAS NG KAHANDAAN NG MGA GURONG MAGSASANAY SA PAGTUTURO NG FILIPINO

EPRA International Journal of Multidisciplinary Research (IJMR)
Ang kurikulum ng undergraduate na edukasyon sa programang Batsilyer sa Edukasyong Pansekundarya ay nagtatakda ng internship o pagsasanay para sa mga gurong magsasanay sa mga paaralan at iba pang mga kasangkot na paaralan. Ito ay nakabatay sa CMO No. 104 s.
null Ruben A. Indita, null Joan S. Bacabac, null Arrianne Jane B. Mabahin, null Jassel Angel Abuda, null Annabelle L. Balderian   +4 more
openaire   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Resilence Control of DC Microgrid Integrated with Multi-Nanogrids Considering Connected-Islanded States

CSEE Journal of Power and Energy Systems
In this paper, a DC microgrid (DCMG) integrated with a set of nano-grids (NG) is studied. DCMG exchanges predetermined active and reactive power with the upstream network. DCMG and NGs are coordinately controlled and managed in such a way the exchanged P-
Hossien Faraji, Reza Hemmati, Pierluigi Siano   +2 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source