Bruton’s tyrosine kinase regulates gut immune homeostasis through attenuating Th1 response
Cell Death and Disease, 2021 Inflammatory bowel disease (IBD) is driven by multiple genetic and environmental risk factors. Patients with mutations in Bruton’s tyrosine kinase (BTK) is known to manifest high prevalence of intestinal disorders including IBD. Although BTK mediates the
Di Guan +4 more
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Inference of Markovian Properties of Molecular Sequences from NGS Data and Applications to Comparative Genomics [PDF]
, 2015 Next Generation Sequencing (NGS) technologies generate large amounts of short read data for many different organisms. The fact that NGS reads are generally short makes it challenging to assemble the reads and reconstruct the original genome sequence. For
Cannon, Charles H. +5 more
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Design e Antropometria: Diferenciação Estratégica
Projetica, 2011 A gestão de design, dentre suas diferentes atribuições, procura e promove informações estratégicas para o processo de design. Tais informações podem, por exemplo, focar na diferenciação dos produtos.
Rodrigo Petry Schoenardie +2 more
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Training in High-Throughput Sequencing: Common Guidelines to Enable Material Sharing, Dissemination, and Reusability. [PDF]
PLoS Computational Biology, 2016 The advancement of high-throughput sequencing (HTS) technologies and the rapid development of numerous analysis algorithms and pipelines in this field has resulted in an unprecedentedly high demand for training scientists in HTS data analysis.
Bastian Schiffthaler +4 more
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SEED: efficient clustering of next-generation sequences. [PDF]
, 2011 MotivationSimilarity clustering of next-generation sequences (NGS) is an important computational problem to study the population sizes of DNA/RNA molecules and to reduce the redundancies in NGS data.
Bao, Ergude +3 more
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Journal of Experimental & Clinical Cancer Research, 2018 The United States Food and Drug Administration (FDA) recently approved the clinical use of two comprehensive ‘mid-size’ Next Generation Sequencing (NGS) panels calling actionable genomic aberrations in cancer.
Matteo Allegretti +7 more
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The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels [PDF]
, 2013 Aim: Topical administration of siRNA nanocarriers is a promising approach in the treatment of pulmonary disorders. Pulmonary surfactant, covering the entire alveolar surface of mammalian lungs, will be one of the first interfaces that siRNA nanocarriers ...
Braeckmans, Kevin +4 more
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Identification and therapeutic evaluation of ALK rearrangements in non‐small‐cell lung cancer
The Journal of Pathology: Clinical Research, 2022 This study aimed to present a comprehensive assessment of anaplastic lymphoma kinase (ALK) rearrangements evaluated by DNA/RNA‐based next‐generation sequencing (NGS) and Ventana immunohistochemistry (IHC) in patients with non‐small‐cell lung cancer ...
Ruiying Zhao +9 more
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Rapid detection of copy number variations and point mutations in BRCA1/2 genes using a single workflow by ion semiconductor sequencing pipeline [PDF]
, 2018 Molecular analysis of BRCA1 (MIM# 604370) and BRCA2 (MIM #600185) genes is essential for familial breast and ovarian cancer prevention and treatment.
Amanti, C +11 more
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Therapeutic Advances in Urology, 2021 Background: Our aim was to compare microorganism detection between standard culture (Ctx) and next generation sequencing (NGS) in patients undergoing surgery for nephrolithiasis; we prospectively compared both urine and stone culture results using these ...
Charles U. Nottingham +6 more
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