Results 81 to 90 of about 229,275 (305)
Diagnostics, 2019 In Italy, 5200 new ovarian cancers were diagnosed in 2018, highlighting an increasing need to test women for BRCA1/2. The number of labs offering this test is continuously increasing.
Ettore Capoluongo +27 more
doaj +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
bgruening/docker-galaxy-ngs-preprocessing: Galaxy 19.01 release
, 2019 :whale::bar_chart::books: Docker Images for NGS data ...
Bérénice Batut, Björn Grüning
core +1 more source
Cancer Management and Research, 2021 Han Bai,1 Jianjun Yu,2 Shidong Jia,2 Xiaoran Liu,1 Xu Liang,1 Huiping Li1 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital and Institute ...
Bai H, Yu J, Jia S, Liu X, Liang X, Li H
doaj
Спектр патогенных вариантов в генах CHEK2, PALB2 и ATM у российских пациенток с раком молочной железы [PDF]
Письма в Вавиловский журнал генетики и селекцииРак молочной железы (РМЖ) является одним из наиболее распространенных онкологических заболеваний среди женщин в Российской Федерации. По мере развития технологий секвенирования появилась возможность проводить поиск причинных мутаций в различных генах,
П.С. Орлов +6 more
doaj +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Etablierung der § 64 LFGB Arbeitsgruppen „NGS – Bakteriencharakterisierung“ und „NGS – Speziesidentifizierung“ [PDF]
, 2019 Das Next-Generation Sequencing (NGS) besitzt großes Potential im Bereich der Lebensmittelsicherheit und der Authentizitätsprüfung von Lebensmitteln. Die Gesamtgenomsequenzierung mikrobieller Genome kombiniert mit bioinformatischen Auswerteprogrammen ...
Szabo, Kathrin +2 more
core +1 more source
, 2023 (a) Phylogeny of PC39-1 HC Ab next generation sequencing (NGS) from donor PC39, colored by time point with the mAbs indicated with black labels. (b) Phylogeny of PC39-1 HC Ab NGS from donor PC39, colored by CDRH1 insertion length with the mAbs indicated ...
Nancy Carrico (16469221) +28 more
core +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source