Results 61 to 70 of about 229,275 (305)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
LAWAK NG PAGGAMIT NG MGA GURO NG MELC SA PAGLINANG NG TATLONG DOMEYN NG PAGKATUTO
Ang pag-aaral na ito ay naglalayong suriin ang lawak ng paggamit ng mga guro ng MELCs (Most Essential Learning Competencies) sa paglinang ng tatlong domeyn ng pagkatuto sa Filipino mula sa pananaw ng mga mag-aaral. Isinagawa ito sa Metro Dumaguete College at ang mga respondente ay binubuo ng 112 mga mag-aaral mula sa Grade 11 at Grade 12, kasama ang ...
Repollo, Jeckson B. +1 more
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Artificial intelligence used in genome analysis studies
The EuroBiotech Journal, 2018 Next Generation Sequencing (NGS) or deep sequencing technology enables parallel reading of multiple individual DNA fragments, thereby enabling the identification of millions of base pairs in several hours.
D’Agaro Edo
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
bgruening/docker-galaxy-ngs-preprocessing: 17.09 release
, 2016 :whale::bar_chart::books: Docker Images for NGS data ...
Bérénice Batut, Björn Grüning
core +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
NGS-MSTB - Example output Web report
, 2019 NGS-MSTB Docker image ships with the pre-computed example of assembling a set of complete RSV genomes. This dataset includes the Web report of the assembly results. It is used when building the Docker image.
Andrey Tovchigrechko (64098) +1 more
core +1 more source