Results 41 to 50 of about 386,400 (307)

A practical, bioinformatic workflow system for large data sets generated by next-generation sequencing [PDF]

, 2010
Transcriptomics (at the level of single cells, tissues and/or whole organisms) underpins many fields of biomedical science, from understanding the basic cellular function in model organisms, to the elucidation of the biological events that govern the ...
Aaron R. Jex, Altschul, Anja Joachim, Ashburner, Bentley, Bethony, Björnberg, Blaxter, Boag, Bronwyn E. Campbell, Caffrey, Campbell, Cantacessi, Cantacessi, Cantacessi, Cantacessi, Chan, Chang, Cinzia Cantacessi, Clifton, Conesa, Cottee, Cottee, Datu, DeRisi, Doyle, Flicek, Freigofas, Gasser, Golden, Greene, Gupta, Hawdon, Hopkins, Hotez, Hu, Huang, Hunter, Iseli, Jackson, Joachim, Joachim, Keil, Krasky, Letunic, Li, Li, Li, Lipinski, Makedonka Mitreva, Margulies, Matthew J. Nolan, McKay, Metzker, Miller, Miller, Mizuarai, Moreno, Morozova, Moser, Mufson, Mulvenna, Nagaraj, Nagaraj, Neil D. Young, Nikolaou, Nisbet, Olson, Parkinson, Paul W. Sternberg, Pong, Portman, Ranganathan, Ren, Robertson, Robin B. Gasser, Robinson, Ross S. Hall, Sahar Abubucker, Sanger, Sanger, Santos, Shoba Ranganathan, Soderlund, Stathopoulos, Stockdale, Tanaka, Vibranovski, Wang, Williamson, Wilson, Wu, Young, Young, Zhan, Zhong   +95 more
core   +6 more sources

AI-accelerated therapeutic antibody development: practical insights

Frontiers in Drug Discovery
Antibodies represent the largest class of biotherapeutics thanks to their high target specificity, binding affinity and versatility. Recent breakthroughs in Artificial Intelligence (AI) have enabled information-rich in silico representations of ...
Luca Santuari, Marianne Bachmann Salvy, Ioannis Xenarios, Ioannis Xenarios, Bulak Arpat   +4 more
doaj   +1 more source

NFIRAOS First Facility AO System for the Thirty Meter Telescope [PDF]

, 2014
NFIRAOS, the Thirty Meter Telescope's first adaptive optics system is an order 60x60 Multi-Conjugate AO system with two deformable mirrors. Although most observing will use 6 laser guide stars, it also has an NGS-only mode. Uniquely, NFIRAOS is cooled to
Andersen, David, Atwood, Jenny, Boyer, Corinne, Byrnes, Peter, Caputa, Kris, Ellerbroek, Brent, Gilles, Luc, Herriot, Glen, Hill, Alexis, Ljusic, Zoran, Pazder, John, Rosensteiner, Matthias, Smith, Malcolm, Spano, Paolo, Szeto, Kei, Véran, Jean-Pierre, Wang, Lianqi, Wevers, Ivan, Wooff, Robert   +18 more
core   +2 more sources

Evaluation of GenDx Protocol for HLA NGS Genotyping Using the Ion Torrent Sequencing Platform

Acta Medica Bulgarica, 2023
The Human Major Histocompatibility Complex (HLA) is the most polymorphic region of the human genome and encodes molecules with a central role in antigen-specific immune responses.
Ormandjieva A., Ivanova M.
doaj   +1 more source

Systematic detection of mosaicism by using digital NGS reveals three new MEN1 mosaicisms

Endocrine Connections, 2022
Purpose: Mosaicism is a feature of several inherited tumor syndromes. Only a few cases of mosaicism have been described in multiple endocrine neoplasia type 1 (MEN1).
Arnaud Lagarde, Grégory Mougel, Lucie Coppin, Magalie Haissaguerre, Lauriane Le Collen, Amira Mohamed, Marc Klein, Marie-Françoise Odou, Antoine Tabarin, Hedia Brixi, Thomas Cuny, Brigitte Delemer, Anne Barlier, Pauline Romanet   +13 more
doaj   +1 more source

New genetic variants of TET2 and ASXL1 identified by next generation sequencing and pyrosequencing in a patient with MDS-RS-MLD and secondary acute myeloid leukemia

Central European Journal of Immunology, 2021
Myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid neoplasms characterized by the presence of cytopenias, ineffective hematopoiesis and frequent transformation into secondary acute myeloid leukemia (secAML).
Monika Małgorzata Adamska, Ewelina Kowal-Wiśniewska, Katarzyna Kiwerska, Adam Ustaszewski, Joanna Czerwińska-Rybak, Zuzanna Kanduła, Marzena Wojtaszewska, Marta Barańska, Łukasz Pruchniewski, Krzysztof Lewandowski, Małgorzata Jarmuż-Szymczak, Lidia Gil   +11 more
doaj   +1 more source

Genetic sampling for estimating density of common species. [PDF]

, 2017
Understanding population dynamics requires reliable estimates of population density, yet this basic information is often surprisingly difficult to obtain.
Cheng, Ellen, Hodges, Karen E, Mills, L Scott, Sollmann, Rahel   +3 more
core  

BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment [PDF]

, 2016
Targeted mutagenesis by the CRISPR/Cas9 system is currently revolutionizing genetics. The ease of this technique has enabled genome engineering in-vitro and in a range of model organisms and has pushed experimental dimensions to unprecedented proportions.
Boel, Annekatrien, Callewaert, Bert, Coucke, Paul, De Paepe, Anne, De Rocker, Nina, Menten, Björn, Steyaert, Wouter, Willaert, Andy   +7 more
core   +2 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

The association between history of appendectomy and gut microbiota composition: a follow-up cross-sectional study

Frontiers in Microbiology
IntroductionThe appendix is thought to act as a regulatory immune organ and gut microbiota reservoir. Although appendectomy is linked to health risks, its impact on the gut microbiota remains understudied.MethodsThis study is conceived as a cross ...
Matija Hadžić, Paul Hammer, Carsten Krumbiegel, Olga Moskalenko, Andrija Karačić, Andrija Karačić, Daria Hadžić   +6 more
doaj   +1 more source