Results 21 to 30 of about 386,400 (307)

Next-Generation Sequencing:Application in Liver Cancer-Past, Present and Future? [PDF]

open access: yes, 2012
Hepatocellular Carcinoma (HCC) is the third most deadly malignancy worldwide characterized by phenotypic and molecular heterogeneity. In the past two decades, advances in genomic analyses have formed a comprehensive understanding of different underlying ...
Daly   +19 more
core   +2 more sources

Comparison of molecular diagnostic approaches for the detection and differentiation of the intestinal protist Blastocystis sp. in humans

open access: yesParasite, 2022
Blastocystis is the most commonly found intestinal protist in the world. Accurate detection and differentiation of Blastocystis including its subtypes (arguably species) are essential to understand its epidemiology and role in human health.
Šloufová Martina   +6 more
doaj   +1 more source

Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence

open access: yesViruses, 2020
While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Laurens Lambrechts   +4 more
doaj   +1 more source

New challenges for Adaptive Optics: Extremely Large Telescopes [PDF]

open access: yes, 2000
The performance of an adaptive optics (AO) system on a 100m diameter ground based telescope working in the visible range of the spectrum is computed using an analytical approach.
A. Tokovinin   +4 more
core   +3 more sources

The spectrum of BRCA1 gene mutations in early onset breast cancer patients from Russia

open access: yesСибирский онкологический журнал, 2018
Aim of the study. Aim of the study was to estimate the occurrence of pathogenic mutations in the BRCA1 gene in Russian breast cancer patients.Material and methods.
M. S. Anisimenko   +11 more
doaj   +1 more source

BamView: visualizing and interpretation of next-generation sequencing read alignments. [PDF]

open access: yes, 2012
So-called next-generation sequencing (NGS) has provided the ability to sequence on a massive scale at low cost, enabling biologists to perform powerful experiments and gain insight into biological processes.
Berriman, Matthew   +5 more
core   +1 more source

An extracellular matrix-related prognostic and predictive indicator for early-stage non-small cell lung cancer

open access: yesNature Communications, 2017
Prognosis and prediction of adjuvant chemotherapy response in non-small cell lung cancer can have significant clinical impact. Here, the authors show that differential expression of a 29 extracellular matrix gene indicator, EPPI, can predict patient ...
Su Bin LIM   +3 more
doaj   +1 more source

Comprehensive Genomic Characterization of a Drug-Resistant Klebsiella pneumoniae Clinical Isolate in Iraq Using Whole Genome Sequencing [PDF]

open access: yesIranian Journal of Medical Sciences
Background: Klebsiella pneumoniae is a Gram-negative encapsulated opportunistic pathogen, which presents a major threat to public health due to its ability for multi-antibiotic drug resistance.
Sarah M.S. Alsallameh   +3 more
doaj   +1 more source

Circulating small RNA signatures differentiate accurately the subtypes of muscular dystrophies: small-RNA next-generation sequencing analytics and functional insights

open access: yesRNA Biology, 2022
Muscular dystrophies are a group of rare and severe inherited disorders mainly affecting the muscle tissue. Duchene Muscular Dystrophy, Myotonic Dystrophy types 1 and 2, Limb Girdle Muscular Dystrophy and Facioscapulohumeral Muscular Dystrophy are some ...
Andrea C. Kakouri   +17 more
doaj   +1 more source

“Mind the Gap”: Hi-C Technology Boosts Contiguity of the Globe Artichoke Genome in Low-Recombination Regions

open access: yesG3: Genes, Genomes, Genetics, 2020
Globe artichoke (Cynara cardunculus var. scolymus; 2n2x=34) is cropped largely in the Mediterranean region, being Italy the leading world producer; however, over time, its cultivation has spread to the Americas and China.
Alberto Acquadro   +4 more
doaj   +1 more source

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