Results 151 to 160 of about 397,632 (265)

Report of treatment intensity and survival outcomes in older patients with glioblastoma diagnosed according to WHO CNS 5 classification. [PDF]

J Neurooncol
Williams ST, Kingdon S, Rominiyi O, Lorimer C, Chandy E, Thompson M, Hill CS, Critchley G, Robinson SD, Histo-Mol GBM collaborative.   +9 more
europepmc   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Health Bill brings NHS management back into government.

BMJ
Alderwick H, Dunn P, Gardner T.
europepmc   +1 more source

Refining prognosis in advanced renal cell carcinoma: international real-world validation of the Meet-URO score in first-line immunotherapy combinations. [PDF]

Oncologist
Rebuzzi SE, Ghose A, Rudman S, Venugopal B, Young K, Frazer RD, Ayodele O, Stares M, O'Carrigan B, Ali W, McGrane J, Jain A, Fiala O, Chauhan V, Michael A, Zarkar A, Kapur G, Charnley N, Afshar M, Vengalil S, Forde C, Brown J, Ürün Y, Bianchini D, Bahl A, Srihari N, Di Costanzo F, Smalley B, Parkes J, Crabb S, Vasudev N, Poprach A, Brown N, James L, Haywood S, Tapia J, Vijay A, Parry J, Cheung M, Mahajan I, Moon NO, Abrol R, Tkadlecová M, Soe YSY, Zargham A, Smith M, Ashley S, Hardy O, Patel G, Tun KK, Johnston E, Sarwer A, Bölek H, Shrestha R, Challapalli A, Meegan J, Anpalakhan S, Buono F, Kolarikova E, Leung DK, Murianni V, Catalano F, Bimbatti D, Buti S, Signori A, Fornarini G, Rescigno P, Teoh JYC, Banna GL.   +68 more
europepmc   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Active protein-capturing hydrogel for broad-spectrum pathogen defense. [PDF]

Sci Adv
Liu J, Hu S, Liu M, Zhang SW, Yan N, Mei X, Zhu D, Shen M, Cheng K.   +8 more
europepmc   +1 more source

The NHS celebrated [PDF]

Journal of the Royal Society of Medicine, 2015
openaire   +2 more sources

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Real-World Functional and Anatomical Outcomes of Intravitreal Faricimab in Suboptimal Responders With Neovascular Age-Related Macular Degeneration: A 24-Month Clinical Audit. [PDF]

Cureus
Sukumaran D, Benjamin D, Abdul Karim MN, Amankwah R, Maharajan P, Mubashar M, Sarmad A, Sharma P, Dhar-Munshi S.   +8 more
europepmc   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source