Results 191 to 200 of about 397,632 (265)

Enhancing Learning Health Systems in Primary and Community Care: Contributions of NHS Library and Knowledge Specialists. [PDF]

Learn Health Syst
Day A, Goswami L.
europepmc   +1 more source

Cobalt/Photoredox Catalyzed Desymmetrization of Oxo and Azabicycles via Asymmetric Reductive Coupling With Alkynes

Advanced Science, EarlyView.
A one‐step, asymmetric reductive coupling of alkynes and oxa‐ and aza‐bicyclic olefins using a cobalt/photoredox catalytic system through desymmetrization. ABSTRACT Bicyclo[2.2.1]heptane frameworks represent a privileged structural motif prevalent in numerous natural products and bioactive molecules.
Subhankar Pradhan, Arko Saha, Bholanath Maity, Sayan Dutta, Luigi Cavallo, Basker Sundararaju   +5 more
wiley   +1 more source

Prospective use of genomics in the evaluation of sudden cardiac death: results from a national health service population pathway. [PDF]

EBioMedicine
Wade C, Sandford R, Elmslie F, Sheppard MN, Richards CJ, Croal B, Osborn M, Ben-Haim Y, Raymundo CE, Hunt L, Mason C, Cox S, Roe C, Samani NJ, Hill S, Williams B, Behr ER, NHS and Coronial Service Sudden Unexpected Death programme group.   +17 more
europepmc   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Tanzkarte NHS

Research and Humanities in Medical Education, 2020
Ruth Chalkley
doaj  

Long-Term Resistance Training and Risk of Type 2 Diabetes.

JAMA Netw Open
Zhang T, Zhang Y, Lee DH, Rezende LFM, Wang X, Zheng C, Giovannucci E.   +6 more
europepmc   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, EarlyView.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

National survey of protocols for day-case hip and knee arthroplasty in the UK. [PDF]

Bone Jt Open
Edwards TA, Large J, French JMR, Evans JT, Reed MR, Whitehouse MR, Day Case Collaborative, Ng ABY, Hosea A, Pradhan A, Date A, Charalambous A, Hunt A, Nakhla A, Firth AM, Metry A, Bolland BJ, Aliker C, Navaratnam DM, Waugh D, Ojelade E, Morriss F, Chadalavada G, Slade G, Higgins G, Neal-Smith G, Umer HM, Noone H, Rankin I, Muhammad I, Ahmed I, Morris J, Roberts J, Hill J, Quayle J, Topping J, Heylen J, Howard J, Moreau J, Roope J, Cumberworth J, Logishetty K, Hogan K, Khilla K, Syam K, Patel K, Kaushik Dash K, Sinan L, Jenner L, Girling L, Choi M, Andrews M, Gibby M, Petrie M, Wilson M, Mubashir Siddiqui M, Bhaskara NV, Flannery O, Kabariti R, Ashour R, Sinnerton R, Azeez S, Everett SJ, Miller S, Hermena S, Mehta S, Bannagham S, Mannan S, Khaleeq T, Maunganidze T, Petheram T, Ross Fraser T, Ng Z.   +72 more
europepmc   +1 more source