Results 171 to 180 of about 60,125,365 (283)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Impacto y aplicación de la NIC 41 agricultura, en el cultivo de cacao en Colombia

, 2018
CONTENIDO PAG Resumen………………………………………………………………..3 Abstract………………………………………………………………...4 Introducción……………………………………………………………5 Objetivo general……………………………………………………….7 Objetivos específicos………………………………………………...7 Marco teórico…………………………………………………………..7 Conclusiones…………………………………………………………..16 Referencias Bibliográficas ...
openaire   +1 more source

As year 12 students enter the chapel for valedictory day eucharist, they receive a traditional farewell, handshakes from year 11 students who line the path, Guildford Grammar School, Perth, Western Australia, 4 November 1994 [picture] /

, 1994
Title from caption list supplied by photographer.; Part of collection: Collection of the life of Guildford Grammar School, Perth, Western Australia, 1994-1995.; Acquired in digital format; access copy available online.; Mode of access: Internet via World
Ellis, Nic (Nicolas Howard) 1955-
core  

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Clinical Efficacy of Neoadjuvant Camrelizumab Plus Chemotherapy for Triple-Negative Breast Cancer and Tumor Immune Microenvironment Analysis: A Prospective-Retrospective Cohort Study. [PDF]

MedComm (2020)
Wang Y, Qiu P, Wang Y, Meng X, Zhang J, Liu H, Shi Z, Zhang Z, Sun X, Wang C, Meng X, Zheng C.   +11 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Interpretable Deep Supramolecular Language Modeling for Cocrystal Design: PCA-Augmented <i>DeepCocrystal</i> Screening of Picolinamide, Nicotinamide, and Isonicotinamide Systems. [PDF]

Molecules
Bozkurt B, Yilmaz A, Ogruc Ildiz G, Fausto R.   +3 more
europepmc   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

High-definition spatial transcriptomics visualizes the cellular and molecular architecture underlying perineural invasion in localized prostate cancer. [PDF]

J Hematol Oncol
Salachan PV, Raaby L, Fredsøe J, Ulhøi B, Borre M, Sørensen KD.   +5 more
europepmc   +1 more source

Relación entre la NIC 41 y la sección 34 de NIIF con relación a la ganadería

, 2018
En este ensayo se abordará la NIC 41 Agricultura y la Sección 34 - actividades especiales de NIIF para las PYMES, haciendo una relación entre las normas y los aspectos relevantes que las diferencian, como también la aplicación que tiene la misma sobre la contabilidad, todo esto ligado a la actividad pecuaria de la ganadería la cual tiene una gran ...
openaire   +1 more source