Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition-Associated Toxicity. [PDF]
ACS Med Chem LettJiang H +10 more
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Impact of cigarette smoking on genetic stability, cell division, and cytotoxicity in buccal cells of old and young women. [PDF]
MutagenesisNersesyan A +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Cigarette Smoke Extract and Nicotine Evoke Similar Interoceptive Effects in a Pavlovian Occasion Setting Task in Male and Female Sprague-Dawley Rats. [PDF]
Nicotine Tob ResSikic A +9 more
europepmc +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The contributions of genetic diversity to the performance of sun-cured tobacco. [PDF]
BMC Plant BiolKurt D, Saygili İ, Kinay A, Karakoc E.
europepmc +1 more source
Impacto y aplicación de la NIC 41 agricultura, en el cultivo de cacao en Colombia
, 2018 En Colombia el impacto de la aplicación de normas Internacionales de Información financiera en el todos los sectores economico ha traído un gran cambio, a pesar de que su convergencia fue algo fuerte, pues a muchas de las compañías o sus gerentes les costó la trasformación por que debían capacitar al personal o contratar a profesionales expertos para
openaire +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Evaluation of neoadjuvant immunotherapy regimens for head and neck squamous cell carcinoma: a systematic review and single-arm and network meta-analysis. [PDF]
Int J SurgYe Z +10 more
europepmc +1 more source