Results 171 to 180 of about 11,890 (257)

Evaluation of neoadjuvant immunotherapy regimens for head and neck squamous cell carcinoma: a systematic review and single-arm and network meta-analysis. [PDF]

Int J Surg
Ye Z, Fan W, Zeng B, Tan R, Yu S, Qiu J, Yang L, Zhang S, Liao G, Li J, Liang Y.   +10 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Research progress of the clinical application of dual-layer spectral computed tomography in gastrointestinal malignancies. [PDF]

World J Radiol
Yan HY, Zhang B, Han ZG, Ren JZ, Liu YQ.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

NF-κB inducing kinase (NIK) deletion accelerates KRAS-driven pancreatic cancer in association with tumor microenvironment remodeling. [PDF]

Cell Death Dis
Du Z, Büttner UFG, Wirth HL, Gerstenlauer M, Manfras U, Loidl R, Bahçeci D, Steiger K, Metzler T, Chan LK, Tsesmelis M, Wirth T.   +11 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Dual-energy CT biomarkers for predicting the efficacy of TACE combined with lenvatinib and immune checkpoint inhibitors in unresectable HCC. [PDF]

Eur Radiol Exp
Zhang J, Zhang K, Du T, Yan C, Wang Y, Gao M, Han J, Zhang M, Chen Y, Zhao L.   +9 more
europepmc   +1 more source

Impacto de la NIC 41 en el sector agricultura, ganadería, silvicultura y pesca: caso Cuenca-Ecuador

, 2017
The impact of IAS 41 was observed on the following accounts: inventories, income tax and accumulated results from the adoption of IFRSs in the companies of the city of Cuenca in the agriculture sector. As a result, the impact was significant for the period 2011-2012, while 38% of the companies if they adopted IFRSs for the first time in the times ...
openaire   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Comparative efficacy of digital health interventions for depression and anxiety symptoms in adolescents and young adults: a systematic review and bayesian network meta-analysis. [PDF]

Child Adolesc Psychiatry Ment Health
Wang H, Yao J, Jia S, Chen W, Guan Y, Liu J, Liao M, Hu E, Zhang Q.   +8 more
europepmc   +1 more source