Results 151 to 160 of about 60,125,365 (283)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

El Acercamiento de la normativa contable europea a las normas del IASB: un reto para 2005

Contabilidad y Auditoría, 2012
Actualmente es de aceptación generalizada la necesidad de un lenguaje contable común. La creciente e imparable globalización de las relaciones económicas y financieras exige disponer de una información comparable, objetiva, transparente y fiable, lo cual
Julita Garcia Diez, Pedro Lorca Fernandez   +1 more
doaj  

Tratamiento contable de un cultivo de acuerdo a lo establecido en la NIC 41

, 2018
Pregrado
openaire   +1 more source

Leksemy dopowiedzeniowe z segmentem „nic”

, 2007
The article presents semantic features of six asyntagmatic contextual lexemes with "nic" segment. Having the same syntactic features, the lexemes play different roles in sentences.
Kisiel, Anna
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Autonomic function and signal complexity reflect level and severity of traumatic spinal cord injury. [PDF]

Spinal Cord
Alhamdan M, Tegenborg Sjöström L, Hånell A, Lewén A, Velle F, Joensen O, Kevci R, Fröjd Revesz D, Sköld MK, Enblad P, Svedung Wettervik T.   +10 more
europepmc   +1 more source

Análisis de la Norma Internacional de Contabilidad 41 (NIC 41-activos biológicos) en las empresas florícolas ubicadas en el cantón Mejía año 2019.

, 2021
El presente trabajo de investigación que tiene por objetivo determinar la fidelidad del valor razonable que tienen las acciones empresariales de las florícolas ubicadas en el Cantón Mejía, y su cumplimiento con los planteamientos de la NIC 41 se lo lleva a cabo a través de una metodología cuantitativa a partir de la cual se da cabida al desarrollo de ...
openaire   +1 more source