Results 131 to 140 of about 11,495 (257)

Brončanodobni nalazi iz karlovačke regije

Arheološki Vestnik, 1989
arcfiif. Karlovac-Region befindet sich um das zentrale Flufigebiet des Flusses Kupa. Vom Cf°l°gischen Gesichtspunkt aus ist dieser Raum ungeniigend erforscht worden. Uber die V d l U n d Mittelbronzezeit herrschen nach wie vor Unklarheiten.
Lazo Čučković
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Halštatske gomile pri Dobrniču

Arheološki Vestnik, 1989
Na pol pota med Žužemberkom in Trebnjim se nahaja južno od Dobrniča starejšeželeznodobna poselitvena celota, ki jo sestavljajo dve višinski naselbini, Cvinger1-3 in še ena manjša severno od njega, ter tri gomilna grobišča (si. 1).
Hermann Parzinger
doaj  

Análisis de la Norma Internacional de Contabilidad 41 (NIC 41-activos biológicos) en las empresas florícolas ubicadas en el cantón Mejía año 2019.

, 2021
El presente trabajo de investigación que tiene por objetivo determinar la fidelidad del valor razonable que tienen las acciones empresariales de las florícolas ubicadas en el Cantón Mejía, y su cumplimiento con los planteamientos de la NIC 41 se lo lleva a cabo a través de una metodología cuantitativa a partir de la cual se da cabida al desarrollo de ...
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Efficacy and Safety of Nicotinamide 10%, Associated with Magnesium Ascorbyl Phosphate 5% and Hyaluronic Acid 5%, Compared to Hydroquinone 4% in Women with Facial Melasma: A Randomized, Double-Blind, Controlled Clinical Trial.

Clinical, Cosmetic and Investigational Dermatology
Mayla Barbosa,1 Rebecca Perez de Amorim,1 Daniel Cassiano,2 Marina Dias,1 Ana Flávia de Abreu,1 Edileia Bagatin,2 Hélio Amante Miot,1 Ana Cláudia Cavalcante Espósito1 1Department of Dermatology, Faculdade de Medicina de Botucatu (UNESP), Botucatu, SP ...
Barbosa M, de Amorim RP, Cassiano D, Dias M, de Abreu AF, Bagatin E, Miot HA, Espósito ACC   +7 more
doaj  

Surgery versus radiotherapy after neoadjuvant immunochemotherapy in limited-stage small cell lung cancer. [PDF]

J Thorac Dis
Zou R, Zhu Z, Teng X, Yu S, Lyu X.
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Intracranial Pressure Monitoring, Heart Rate Variability, Baroreflex Sensitivity, and Signal Complexity During Neurointensive Care after Decompressive Craniectomy in Malignant Middle Cerebral Artery Infarction. [PDF]

Neurocrit Care
Alhamdan M, Hånell A, Howells T, Joensen O, Velle F, Lewén A, Enblad P, Svedung Wettervik T.   +7 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source