Results 221 to 230 of about 11,890 (257)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Cell death mechanisms induced by gold nano-immunoconjugates-mediated photodynamic therapy against human oesophageal cancer stem cells. [PDF]

Front Immunol
Didamson OC, Chandran R, Abrahamse H.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The Role of Neutrophils and NETosis in Diseases: The Implications for Therapy. [PDF]

MedComm (2020)
Ma Z, Wang Q, Zhang Y, Li Y, Wu H, Yang H, Li X.   +6 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

RNA isoform diversity, splicing variants and switching in single cells of the Alzheimer's disease brain. [PDF]

Commun Biol
Shahnaee A, Liu CS, Ngo T, Palmer CR, Ziomek D, Park C, Tan VP, Jimenez NL, Chun J.   +8 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Depressive and Anxiety Symptoms Among Asian American Sexual and Gender Minoritized Youth Experiencing SOGIE- and Race-Based Bullying: A Multivariate Analysis of the Role of Social Support. [PDF]

Ann LGBTQ Public Popul Health
Sun NY, McCauley PS, Rider GN, Lessard LM, Del Farno AJ, Eaton LA, Watson RJ.   +6 more
europepmc   +1 more source

Effects of nicorandil on inflammatory response, oxidative stress and myocardial fibrosis after myocardial infarction. [PDF]

BMC Cardiovasc Disord
Peng J, Hu L, Xiao P, Xiang T, Huang M, Li R, Lei J, Yang Z, Dai X.   +8 more
europepmc   +1 more source

Genetic determinants of hypervirulence with attenuated pathogenicity in a <i>bla</i>_NDM-1-encoding <i>Klebsiella pneumoniae</i> causing neonatal sepsis. [PDF]

Virulence
Nath D, Dhar R, Bhattacharjee A, Das S, Dhar Chanda D, Borah PK, Basu S.   +6 more
europepmc   +1 more source